...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>African Journal of Pharmacy and Pharmacology >Investigation of hemotoxicologic potential of an ayurvedic preparation Kutajarista used in Sprue syndrome after chronic administration to male Sprague-Dawley rats
【24h】

Investigation of hemotoxicologic potential of an ayurvedic preparation Kutajarista used in Sprue syndrome after chronic administration to male Sprague-Dawley rats

机译：慢性综合治疗慢性综合治疗慢性综合治疗雄性Sprague-Dawley大鼠血液综合征血液毒理学潜力的调查

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The ayurvedic medicinal system is the world’s most primitive medical systems which were originated in India. For the treatment of Sprue syndrome, a very well-known ayurvedic preparation named Kutajarista (KTJ) is used in the south Asian region. This study aimed to detect the impact of chronic administration of KTJ on hematological parameters. The experimental animals were subdivided into two groups. A high dose (50 mL/kg) of body weight was given to the first group for 42 days and the second group which was considered as the control group was treated with normal water for the same period. There was a remarkable reduction [10.37%, p=0.092] in the total numbers of red blood cells (RBC). A prominent decrease [10.75%. p=0.097] is also observed in the hemoglobin content of the blood. There was a noticeable [11.05%, p=0.077] decrease in the hematocrit level of the blood and a very high [64.35%, p=0.19] increase in the number of white blood cell (WBC) count of the male Sprague-Dawley rat. A remarkably high increase was observed in the absolute count of Neutrophils (220.161%, p=0.12), Eosinophils (368.75%, p=0.11), Lymphocytes [11.29%, p=0.06], and Monocyte [142.781%, p=0.13] count. Also a prominent [↑ 14.15%, p=0.42] increase in the number of platelet counts was observed. Rat cutaneous tail bleeding time and whole blood clotting time shortening were also observed and the result is statistically prominent. As the result shows a significant change in different hematological parameter it can be summarized that KTJ have potential hemotoxicity at a higher dose. Further study is required at a lower dose.
机译：阿育吠陀药物系统是世界上起源于印度的最原始的医疗系统。对于突出综合征的治疗，南亚地区使用了一个名为Kutajarista（KTJ）的非常众所周知的阿育吠陀制剂。本研究旨在检测慢性施用KTJ对血液学参数的影响。实验动物细分为两组。将高剂量（50ml / kg）的体重给予第一个组42天，并将第二组被认为是对照组的同一水分处理。红细胞总数（RBC）的总数显着减少[10.37％，p = 0.092]。突出的减少[10.75％。在血液的血红蛋白含量中也观察到p = 0.097]。血细胞比容水平的血细胞比容水平降低，血液细胞比容水平和雄性Sprague-Dawley的白细胞（WBC）数量增加[64.35％，P = 0.19]增加[64.35％，P = 0.19]鼠。在中性粒细胞的绝对计数（220.161％，p = 0.12），嗜酸性粒细胞（368.75％，p = 0.11），淋巴细胞[11.29％，p = 0.06]，和单核细胞中的显着高增加[142.781％，p = 0.13 ] 数数。突出的[14.15％，p = 0.42]观察到的血小板计数的数量增加。还观察到大鼠皮肤尾部出血时间和全血凝固时间缩短，结果是统计学上突出的。结果表明，不同血液学参数的显着变化，可以概括KTJ在更高剂量下具有潜在的血小毒性。进一步的研究是以较低剂量的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号