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首页> 外文期刊>European Journal of Histochemistry >Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study
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Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study

机译：睫状神经营养因子（CNTF）及其受体（CNTFRα）信号通过MAPK / ERK途径在人前列腺组织中：形态学和生物分子研究

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摘要

Ciliary neurotrophic factor (CNTF) is a member of interleukin-6 type cytokine family. The CNTF receptor complex is a heterodimer including gp130 and CNTF receptor α (CNTFRα) proteins triggering the activation of multiple intracellular signaling pathways including AKT/PI3K, MAPK/ERK and Jak/STAT pathways. At present no data are available on the localization of CNTF and CNTFRα in prostate as well as on the role of CNTF in this organ. In this study we have analyzed the localization of CNTF and CNTFRα by immunohistochemistry and we have used PWR-1E cell line as a model for normal glandular cell to investigate the role of this cytokine. Our results show that CNTF and CNTFRa are expressed in the staminal compart of the prostate and that CNTF selectively inhibits ERK pathway. In conclusion, we suggest that CNTF could be considered as key molecule to maintenance epithelium homeostasis via pERK downregulation by an autocrine mechanism. Further CNTF studies in prostate cancer could be useful to verify the potential role of this cytokine in carcinogenesis.
机译：睫状神经营养因子（CNTF）是白细胞介素-6型细胞因子家族的成员。 CNTF受体复合物是包括GP130和CNTF受体α（CNTFRα）蛋白的异二聚体，触发包括AKT / PI3K，MAPK / ERK和JAK / STAT途径的多个细胞内信号传导途径的激活。目前没有数据可以在前列腺中的CNTF和CNTFRα的定位上以及CNTF在该器官中的作用。在这项研究中，我们通过免疫组织化学分析了CNTF和CNTFRα的定位，并且我们使用了PWR-1E细胞系作为正常腺细胞的模型，以研究该细胞因子的作用。我们的结果表明，CNTF和CNTFRA在前列腺的贴花组合中表达，CNTF选择性地抑制ERK途径。总之，我们建议CNTF通过自分泌机制通过PERK下调，CNTF可以被认为是对维持上皮稳态的关键分子。前列腺癌中的其他CNTF研究可用于验证该细胞因子在致癌中的潜在作用。

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