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首页> 外文期刊>European Heart Journal - Case Reports >Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report
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Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report

机译：具有异常冠状动脉供应功能性纵隔阳性腺激性的创新方法：案例报告

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Background Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours. Case Summary A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Investigations revealed a large non-metastatic functional mediastinal PG irrigated mainly by a left circumflex coronary anomalous feeder branch. The surgical risk was deemed very high due to patient comorbidities, tumour vascularization, and close relation to major thoracic structures. A multidisciplinary team decided to perform embolization of the anomalous coronary branch followed by peptide-receptor radionuclide therapy with 177-LuDOTATE aiming to decrease tumour size and perioperative risk. Follow-up studies showed a reduction in tumour vascularization, size, and hormonal production. Discussion The innovative strategy of combining embolization of the anomalous feeder branch with radionuclide therapy proved to be a promising approach.
机译：背景技术纵隔伞形Liomas（PGS）是罕见的，特别是挑战性神经内分泌肿瘤。临床介绍是异质的，肿瘤切除由于出血而挑战，功能性肿瘤中儿茶胺潮涌的风险。案例摘要亚急性心力衰竭患有多种心血管危险因素的36岁男性。调查显示出一种主要由左环形冠状体内饲养饲料分支灌溉的大型非转移功能纵隔PG。由于患者的患者，肿瘤血管形成和与主要胸部结构密切相关，手术风险被视为非常高。多学科团队决定进行异常冠状动脉分支的栓塞，然后进行肽受体放射性核素治疗，其旨在降低肿瘤大小和围手术期风险。随访研究表明肿瘤血管化，尺寸和荷尔蒙生产的降低。讨论用放射性核素疗法栓塞栓塞栓塞的创新策略被证明是一种有前途的方法。

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