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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis
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A Network Pharmacology Approach to Explore Mechanism of Action of Longzuan Tongbi Formula on Rheumatoid Arthritis

机译：一种探讨龙龙桐柏公式对类风湿性关节炎作用机制的网络药理学方法

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摘要

Longzuan Tongbi Formula (LZTB) is an effective proved prescription in Zhuang medicine for treating active rheumatoid arthritis (RA). However, its active ingredients, underlying targets, and pharmacological mechanism are still not clear in treating RA. We have applied network pharmacology to study LZTB and found that 8 herbs in LZTB and 67 compounds in the 8 herbs are involved in the regulation of RA-related genes; we have conducted pathway analysis of overlapping genes and found that 7 herbs participate in the regulations of 24 pathways associated with RA and that 5 herbs in the 7 herbs and 25 compounds in the 5 herbs participate in the regulation of hsa05323 (rheumatoid arthritis). The results indicated that all herbs in LZTB and some compounds in those herbs participate in the treatment of RA; 25 compounds are main active ingredients and hsa05323 (rheumatoid arthritis) is the major pathway in the treatment of RA. We have also found that three pathways (inflammatory mediator regulation of TRP channels, PPAR signaling pathway, and mTOR signaling pathway) might have some effect on the treatment of RA.
机译：龙龙桐柏公式（LZTB）是庄医药的有效探明处方，用于治疗活性类风湿性关节炎（RA）。然而，其活性成分，潜在的靶标和药理机制仍然尚不清楚治疗RA。我们已经应用了网络药理学来研究LZTB，发现LZTB中的8种草药和8种草药中的67种化合物参与了RA相关基因的调节;我们已经进行了重叠基因的途径分析，发现7个草药参与与Ra相关的24个途径的规定，并且在7种草草中的5种草药和5种草药中的25种化合物参与了HSA05323（类风湿性关节炎）的调节。结果表明，在LZTB中的所有草药和这些草药中的一些化合物参与了RA的治疗; 25化合物是主要活性成分，HSA05323（类风湿性关节炎）是治疗RA的主要途径。我们还发现三种途径（TRP通道的炎症调解介质调节，PPAR信号通路和MTOR信号通路）可能对RA的处理产生一些影响。

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