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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Circulating CD14+HLA-DR?/low Myeloid-Derived Suppressor Cells as Potential Biomarkers for the Identification of Psoriasis TCM Blood-Heat Syndrome and Blood-Stasis Syndrome
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Circulating CD14+HLA-DR?/low Myeloid-Derived Suppressor Cells as Potential Biomarkers for the Identification of Psoriasis TCM Blood-Heat Syndrome and Blood-Stasis Syndrome

机译：循环CD14 + HLA-DR？/低骨髓衍生的抑制细胞作为潜在的生物标志物，用于鉴定牛皮癣TCM血液热综合征和血瘀综合征

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Psoriasis is a chronic autoimmune disease. Identification of the biomarkers responsible for Traditional Chinese Medicine (TCM) syndromes of psoriasis can help researchers recognize the different aspects of psoriasis and find novel therapeutic targets for the treatment of psoriasis. The current study investigated the levels of circulating Mo-MDSCs and Mo-MDSC-associated immune factors in the peripheral blood of psoriasis patients with different TCM syndromes. We found that the frequency of Mo-MDSCs (CD14+HLA-DR?/low cells) among CD14+ cells from plaque psoriasis patients with blood-stasis (BS) syndrome was significantly increased when compared with healthy controls p0.001 and blood-heat (BH) syndrome group p0.001, respectively. However, serum IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ, iNOS, Arg-1, and NO concentration showed no statistically significant difference between healthy controls and psoriasis patients as well as no significant difference between the BH and BS syndrome groups. Compared with healthy controls, the mRNA expression of Arg-1, TNF-α, ROR-γ, and PD-L1 was increased, while the mRNA expression of PD-1 and IL-10 was decreased in PBMCs from psoriasis patients. Moreover, the mRNA expression of TNF-α and FOXP3 in PBMCs showed a pronounced statistical difference between the psoriatic BH syndrome group and the BS syndrome group. Therefore, we provide evidence that the percentage of CD14+HLA-DR?/low MDSC/ CD14+ cells and TNF-α and Foxp3 mRNA expression levels in PBMCs are potential biomarkers for distinguishing TCM BH syndrome and BS syndrome.
机译：牛皮癣是一种慢性自身免疫性疾病。鉴定牛皮癣的中药综合征负责的生物标志物可以帮助研究人员认识到牛皮癣的不同方面，并找到用于治疗牛皮癣的新疗法靶标。目前的研究研究了不同中医综合征的牛皮癣患者外周血中循环MO-MDSC和MO-MDSC相关免疫因子的水平。我们发现，与健康对照P <0.001和血液 - 热量相比，来自斑块牛皮癣（BS）患者的CD14 +细胞中MO-MDSCs（CD14 + HLA-DRα/低细胞）的频率显着增加（BH）综合征组P <0.001分别。然而，血清IL-2，IL-4，IL-6，IL-10，IL-17A，TNF-α，IFN-γ，INOS，ARG-1，并且没有浓度在健康对照和牛皮癣之间没有统计学显着差异患者以及BH和BS综合征组之间没有显着差异。与健康对照相比，Arg-1，TNF-α，ROR-γ和PD-L1的mRNA表达增加，而PD-1和IL-10的mRNA表达在牛皮癣患者中的PBMC中降低。此外，PBMC中TNF-α和FOXP3的mRNA表达显示了银屑病BH综合征组和BS综合征组之间的明显统计差异。因此，我们提供了CD14 + HLA-DR的百分比，PBMC中的CD14 + HLA-DR？/低MDSC / CD14 +细胞和TNF-α和FOXP3 mRNA表达水平是用于区分中医BH综合征和BS综合征的潜在生物标志物。

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