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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology
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Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology

机译：基于网络药理学治疗鼻咽癌治疗鼻咽癌的药物靶标和分子机制研究

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Aim. To analyse the target of Rhizoma Curcumae in nasopharyngeal carcinoma by using network pharmacological techniques and to explore the associated molecular mechanism. Methods. The targets of nasopharyngeal carcinoma were retrieved from the GeneCards database. At the same time, the drug therapeutic targets of Rhizoma Curcumae were obtained from the TCMSP and SymMap databases. The data were imported into the STRING database and Cytoscape 3.7.1 to construct a network of “Chinese medicine component-target-disease” interactions; then, the intersection was screened as the core Rhizoma Curcumae antinasopharyngeal cancer targets. Through GO target function and KEGG pathway enrichment analyses of the core targets, we predicted the biological processes and key signalling pathways involved in the Rhizoma Curcumae treatment of nasopharyngeal carcinoma. Results. Twenty-five core targets of Rhizoma Curcumae in nasopharyngeal carcinoma were mined: TP53, BCL2 ICAM1 RXRA, TLR3 and TLR9, TNF, PTGS2, IL-6, CTSD, MMP2, MMP9, MMP14, TIMP2, ABCC1, ABCB1, ABCG2, and so on. The results of visual analysis showed that the Rhizoma Curcumae treatment of nasopharyngeal carcinoma mainly involves leukocyte adhesion to vascular endothelial cells, positive regulation of NF-κB import into the nucleus, regulation of the reactive oxygen species biosynthetic and metabolic process, regulation of the chemokine biosynthetic and metabolic process, various cancer-related signalling pathways, and a variety of cytokine signal transduction pathways, such as the NF-κB, TLR, IL-17, and TNF signalling pathways. Conclusion. The core targets predicted by our research can be used as molecular markers for the treatment and prediction of nasopharyngeal carcinoma. The mechanism of Rhizoma Curcumae treatment in NPC may be related to immune regulatory pathways, the inhibition of cancer cell proliferation, metastasis, and angiogenesis, as well as the regulation of tumour microenvironment. Combined with the prediction of its associated mechanism of action, the core targets can provide targeted reference value for subsequent drug development related to Curcuma.
机译：目标。利用网络药理学技术分析鼻咽癌中鼻咽癌的靶标，探讨相关分子机制。方法。从Genecards数据库中检索鼻咽癌的靶标。同时，从TCMSP和Symmap数据库获得Rhizoma Curcumae的药物治疗靶。将数据导入串数据库和Cytoscape 3.7.1以构建“中药组分 - 疾病”相互作用的网络;然后，筛选交叉点作为核心莪术抗胰腺癌靶标。通过GO目标函数和KEGG途径富集分析核心目标，我们预测了患有鼻咽癌的Rhizoma Curcumae治疗的生物过程和关键信号途径。结果。开采鼻咽癌中的二十五个核心莪术在鼻咽癌中：TP53，BCL2 ICAM1 RXRA，TLR3和TLR9，TNF，PTGS2，IL-6，CTSD，MMP2，MMP9，MMP14，TIMP2，ABCC1，ABCB1，ABCG2等上。目视分析结果表明，鼻咽癌的神经细胞治疗对血管内皮细胞的白细胞粘附，NF-κB的正调节进口到细胞核，调节反应性氧物种生物合成和代谢过程，调节趋化因子生物合成和代谢过程，各种癌症相关的信号传导途径和各种细胞因子信号转导途径，例如NF-κB，TLR，IL-17和TNF信号通路。结论。我们的研究预测的核心目标可以用作治疗和预测鼻咽癌的分子标记。 NPC中Rhizoma Curcumae治疗机制可能与免疫调节途径有关，抑制癌细胞增殖，转移和血管生成，以及肿瘤微环境的调节。结合预测其相关机制的作用机制，核心靶标可以为与莪术相关的后续药物发育提供靶向参考值。

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