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首页> 外文期刊>Genes and Nutrition >Quercetin can reduce insulin resistance without decreasing adipose tissue and skeletal muscle fat accumulation
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Quercetin can reduce insulin resistance without decreasing adipose tissue and skeletal muscle fat accumulation

机译：槲皮素可以减少胰岛素抗性而不降低脂肪组织和骨骼肌脂肪积累

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Quercetin exhibits a wide range of biological functions. The first aim of the present work was to analyze the effects of quercetin on fat accumulation in adipose tissue and glycemic control in rats. Any potential involvement of muscle fatty acid oxidation in its effect on glycemic control was also assessed. Animals were fed a high-fat high-sucrose diet either supplemented with quercetin (30?mg/kg body weight/day), or not supplemented, for 6?weeks. One week before killing, a glucose tolerance test was carried out. Muscle triacylglycerol content, serum glucose, insulin, fructosamine and free fatty acids were measured, and homeostatic model assessment for insulin resistance (HOMA-IR) was calculated. The activities of lipogenic enzymes and lipoprotein lipase in adipose tissue, carnitine palmitoyl transferase-1b (CPT-1b) and citrate synthase in skeletal muscle, and the expression of several genes, ACO, CD36, CPT-1b, PPAR-α, PGC-1α, UCP3, TFAM and COX-2 in skeletal muscle were analyzed. Quercetin caused no significant reduction in body weight or adipose tissue sizes. However, fructosamine, basal glucose and insulin, and consequently HOMA-IR, were significantly reduced by quercetin. No changes were observed in the activity of lipogenic enzymes and lipoprotein lipase. Muscle triacylglycerol content was similar in both experimental groups. The expression of ACO, CD36, CPT-1b, PPAR-α, PGC-1α, UCP3, TFAM and COX-2 remained unchanged. It can be concluded that quercetin is more effective as an anti-diabetic than as an anti-obesity biomolecule. The improvement in insulin resistance induced by this flavonoid is not mediated by a delipidating effect in skeletal muscle.
机译：槲皮素表现出广泛的生物功能。本作本作的首次目的是分析槲皮素对大鼠脂肪组织和血糖控制脂肪积累的影响。还评估了肌肉脂肪酸氧化在其对血糖对照的影响中的任何潜在累及。将动物喂养高脂肪高蔗糖饮食，其补充有槲皮素（30×mg / kg体重/日），或不补充6？周。杀死前一周，进行葡萄糖耐量试验。测量肌肉三酰基甘油含量，血清葡萄糖，胰岛素，果糖胺和游离脂肪酸，并计算胰岛素抵抗（HOMA-IR）的稳态模型评估。脂肪组织中脂肪生酶和脂蛋白脂肪酶的活性，肉毒氨基棕榈酰转移酶-1b（CPT-1b）和柠檬酸合酶在骨骼肌中，以及几种基因，ACO，CD36，CPT-1b，PPAR-α，PGC-的表达分析了骨骼肌中的1α，UCP3，TFAM和COX-2。槲皮素不会显着降低体重或脂肪组织尺寸。然而，果糖胺，基础葡萄糖和胰岛素，并因此通过槲皮素显着降低了HOMA-IR。在脂质酶和脂蛋白脂肪酶的活性中没有观察到任何变化。两种实验组中肌肉三酰基甘油含量相似。 ACO，CD36，CPT-1B，PPAR-α，PGC-1α，UCP3，TFAM和COX-2的表达保持不变。可以得出结论，槲皮素与抗糖尿病素更有效，而不是抗肥胖生物分子。该类黄酮诱导的胰岛素抵抗的改善不是通过骨骼肌中的曲化作用来介导。

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