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首页> 外文期刊>Genomics >iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC
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iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC

机译：idna6ma-pseknc：通过将核苷酸物理化学性能掺入pseknc中来识别DNA N6-甲基腺苷位点

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摘要

N6-methyladenine (6mA) is one kind of post-replication modification (PTM or PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will be very helpful for revealing the biological functions of 6mA, but it is time-consuming and expensive to determine them by experiments alone. Unfortunately, so far, no bioinformatics tool is available to do so. To fill in such an empty area, we have proposed a novel predictor called iDNA6mA-PseKNC that is established by incorporating nucleotide physicochemical properties into Pseudo K-tuple Nucleotide Composition (PseKNC). It has been observed via rigorous cross-validations that the predictor's sensitivity (Sn), specificity (Sp), accuracy (Acc), and stability (MCC) are 93%, 100%, 96%, and 0.93, respectively. For the convenience of most experimental scientists, a user-friendly web server for iDNA6mA-PseKNC has been established at http://lin-group.cn/server/iDNA6mA-PseKNC, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved.
机译：N6-甲基腺嘌呤（6mA）是在各种DNA序列中发生的一种复制后修饰（PTM或PTRM）。准确识别其网站对揭示6mA的生物学功能非常有帮助，但通过实验来确定它们是耗时和昂贵的。不幸的是，到目前为止，没有生物信息工具可以这样做。为了填充这样的空区，我们提出了一种称为IDNA6MA-PSEKNC的新型预测因子，其通过将核苷酸物理化学特性掺入假k组核苷酸组合物（PSEKNC）中来建立。已经通过预测器的敏感性（SN），特异性（SP），精度（ACC）和稳定性（MCC）分别通过预测器的敏感性（SN），特异性（SP），稳定性（MCC）分别为93％，100％，96％和0.93。为了方便大多数实验科学家，在http://lin-group.cn/server/idna6ma-pseknc中建立了一个用于idna6ma-pseknc的用户友好的Web服务器，用户可以在没有需要的情况下轻松获得所需的结果通过所涉及的复杂数学方程式。

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