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New insights into the epigenetics of osteoporosis

机译：新见解骨质疏松症的表观学

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Osteoporosis is characterized by reduced bone formation and accumulation of adipocytes in the bone marrow compartment. The decrease in bone mass results from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The deficiency of bone cells to replace the resorpted bone can be due to a preferential differentiation of bone marrow stromal cells into adipocytes at the expense of osteoblasts. Consequently, the processes that control the differentiation of osteoclasts, osteoblasts and adipocytes play a crucial role in bone metabolism. It is known that epigenetic mechanisms are critical regulator of the differentiation programs for cell fate and moreover are subject to changes during aging. Here, we summarize recent findings on the role of epigenetics in the modulation of mechanisms that may be associated with osteoporosis. In particular, we focus on disturbances in the bone remodeling process described in human studies that address the epigenetic regulation of the osteoblast/adipocyte balance.
机译：骨质疏松症的特征在于骨髓室中的骨形成和脂肪细胞的积累。骨质量降低是由于骨骨骨膜介导的骨吸收和成骨细胞介导的骨形成之间的不平衡。骨细胞的缺乏替代复苏骨可以是由于骨髓基质细胞的优先分化成抗成骨细胞的脂肪细胞。因此，控制骨细胞，成骨细胞和脂肪细胞的分化的过程在骨代谢中发挥着至关重要的作用。众所周知，表观遗传机制是细胞命运的分化计划的临界调节剂，而且随着老化期间的变化可能会发生变化。在这里，我们总结了最近关于表观遗传学在可能与骨质疏松症相关的机制的作用的结果。特别是，我们专注于人类研究中描述的骨改造过程中描述的紊乱，这些过程解决了骨赘/脂肪细胞平衡的表观遗传调节。

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