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Comparative study on seasonal hair follicle cycling by analysis of the transcriptomes from cashmere and milk goats

机译：羊毛和牛奶山羊转录om季节性毛囊循环循环循环的比较研究

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Guard hair and cashmere undercoat are developed from primary and secondary hair follicle, respectively. Little is known about the gene expression differences between primary and secondary hair follicle cycling. In this study, we obtained RNA-seq data from cashmere and milk goats grown at four different seasons. We studied the differentially expressed genes (DEGs) during the yearly hair follicle cycling, and between cashmere and milk goats. WNT, NOTCH, MAPK, BMP, TGFβ and Hedgehog signaling pathways were involved in hair follicle cycling in both cashmere and milk goat. However, Milk goat DEGs between different months were significantly more than cashmere goat DEGs, with the largest difference being identified in December. Some expression dynamics were confirmed by quantitative PCR and western blot, and immunohistochemistry. This study offers new information sources related to hair follicle cycling in milk and cashmere goats, which could be applicable to improve the wool production and quality.
机译：保护头发和羊绒底涂层分别由初级和次级毛囊开发。关于初级和二次毛囊循环之间的基因表达差异很少。在这项研究中，我们从四个不同季节生长的羊绒和牛奶山羊的RNA-SEQ数据获得了RNA-SEQ数据。我们在年毛囊循环期间和羊绒和牛奶山羊之间研究了差异表达的基因（DEGS）。 WNT，缺口，MAPK，BMP，TGFβ和Hedgehog信号通路涉及羊绒和牛奶山羊的毛囊循环。然而，不同月份之间的牛奶山羊比赛比羊绒山羊山脉在羊绒山羊之间，在12月份的差异最大。通过定量PCR和Western印迹和免疫组化证实了一些表达动态。本研究提供了与牛奶和羊绒山羊骑自行车的新信息来源，可适用于改善羊毛生产和质量。

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