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Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

机译：结核病感染和肺腺癌：从不吸烟的亚洲女性基因组关联研究数据的孟德利安随机化和途径分析

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We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p?=?0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR?=?1.31, 95% CI: 1.03, 1.66, p?=?0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
机译：我们调查了对结核病（TB）的遗传易感性是否影响了使用TB基因组协会研究（GWAS）在亚洲女性肺癌联盟中的Never-Saplers之间的肺腺癌发育。使用自适应等级截短产品方法的途径分析用于评估TB相关基因组和肺腺癌之间的关联，使用来自5512肺腺癌病例和6277个对照的GWAS数据。基因组由31种基因组成，含有来自先前Tb-Gwas的遗传变体的已知/暗示缔合的基因。随后，我们随访孟德尔随机化，使用来自以前的东亚人群的三种基因组显着的显着变体评估Tb和肺腺癌之间的关联。 TB相关的基因组与肺腺癌有关（P？= 0.016）。此外，孟德尔随机化显示TB和肺腺癌之间的关联（或？=α1.31,95％CI：1.03,1.66，P？= 0.027）。我们的研究结果支持TB作为从未吸烟亚洲女性中肺癌发育的因果危险因素。

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