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首页> 外文期刊>Genomics >Genomic survey of RNA recognition motif (RRM) containing RNA binding proteins from barley (Hordeum vulgare ssp. vulgare)
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Genomic survey of RNA recognition motif (RRM) containing RNA binding proteins from barley (Hordeum vulgare ssp. vulgare)

机译：来自大麦RNA结合蛋白的RNA识别基序（RNM）的基因组调查（Hordeum Vulgare SSP。耐瓜

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摘要

One of the major mechanisms of post-transcriptional gene regulation is achieved by proteins bearing well-defined sequence motifs involved in ‘RNA binding’. In eukaryotes, RNA binding proteins (RBPs) are key players of RNA metabolism that includes synthesis, processing, editing, modifying, transport, storage and stability of RNA. In plants, the family of RBPs is vastly expanded compared to other eukaryotes including humans. In this study we identified 363 RBPs in the barley genome. Gene ontology enrichment analysis of barley RBPs indicated these proteins were in all the major cellular compartments and associated with key biological processes including translation, splicing, seed development and stress signaling. Members with the classical RNA binding motifs such as the RNA recognition motif (RRM), KH domain, Helicase, CRM, dsRNA and Pumilio were identified in the repertoire of barley RBPs. Similar to Arabidopsis, the RRM containing RBPs were the most abundant in barley genome. In-depth analysis of the RRM containing proteins - polyA binding proteins, Ser/Arg rich proteins and Glycine-rich RBPs were undertaken. Reanalysis of the proteome dataset of various stages during barley malting identified 38 RBPs suggesting an important role for these proteins during the malting process. This survey provides a systematic analysis of barley RBPs and serves as the basis for the further functional characterization of this important family of proteins.
机译：转录后基因调节的主要机制之一是通过载有涉及“RNA结合”的明确定义的序列基序的蛋白质来实现。在真核生物中，RNA结合蛋白（RBP）是RNA代谢的关键球员，包括合成，加工，编辑，改性，转运，RNA储存和稳定性。在植物中，与包括人类在内的其他真核生物相比，RBPS家族大大扩大。在这项研究中，我们在大麦基因组中识别了363个RBP。大麦的基因本体浓缩分析显示这些蛋白质在所有主要细胞室中，与关键生物过程相关，包括翻译，剪接，种子发育和应力信号传导。在大麦RBP的曲目中鉴定了具有RNA识别基因铟（RRM），KH结构域，旋光酶，CRM，DSRNA和Pumilio的典型RNA结合基序的成员。与拟南芥类似，含有Rbps的RRM是大麦基因组最丰富的RBP。对含有蛋白质的RRM的深入分析 - 多A结合蛋白，SER / Arg富蛋白质和富含甘氨酸富含RBP。在大麦麦芽化期间的各个阶段的蛋白质组数据集的再分析确定了38个RBP，表明在麦芽过程中对这些蛋白质的重要​​作用。该调查提供了对大麦RBP的系统分析，并作为这一重要蛋白质的进一步函数表征的基础。

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