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Predicting subcellular localization of proteins using protein-protein interaction data

机译:使用蛋白质 - 蛋白质相互作用数据预测蛋白质的亚细胞定位

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The knowledge of subcellular localization of proteins can provide useful clues about their functions. The conventional methods to determine the subcellular localization are unable to keep pace with the rate at which the new data is being generated. Thus, though sequence information is available, the localization and function of a number of proteins remains unknown. In this study, we have developed a script that makes use of the physical interactors of a protein and their localization data to predict the subcellular localization. We used the script to predict the localization of yeast proteins for which there is no localization data. Further, we experimentally verified the predicted localization for six arbitrarily chosen proteins and found our predictions to be correct for five of the proteins.
机译:蛋白质亚细胞定位的知识可以为其功能提供有用的线索。确定亚细胞定位的传统方法无法跟上生成新数据的速率。因此,尽管序列信息可用,但是许多蛋白质的定位和功能仍然未知。在这项研究中,我们开发了一种脚本,它利用蛋白质的物理交互和其定位数据来预测亚细胞定位。我们使用脚本来预测酵母蛋白的定位,没有本地化数据。此外,我们通过实验验证了六种任意选择的蛋白质的预测本地化,并发现我们的预测是对5种蛋白质的正确性。

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