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The relationship between the minor allele content and Alzheimers disease

机译：次要等位基因含量与阿尔茨海默病之间的关系

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Alzheimers disease (AD) is a chronic neurodegenerative disease. The genetic risk factors of AD remain better understood. Using previously published dataset of common single nucleotide polymorphisms (SNPs), we studied the association between the minor allele content (MAC) in an individual and AD. We found that AD patients have higher average MAC values than matched controls. We identified a risk prediction model that could predict 2.19% of AD cases. We also identified 49 genes whose expression levels correlated with both MAC and AD. By pathway and process enrichment analyses, these genes were found in pathways or processes closely related to AD. Our study suggests that AD may be linked with too many genetic variations over a threshold. The method of correlations with both MAC and traits appears to be effective in high efficiency identification of target genes for complex traits.
机译：阿尔茨海默病病（AD）是一种慢性神经变性疾病。广告的遗传危险因素仍然更好地理解。使用先前公布的常见单核苷酸多态性（SNP）的数据集，我们研究了个体和广告中的次要等位基因含量（MAC）之间的关联。我们发现广告患者具有比匹配的对照更高的平均MAC值。我们确定了一个风险预测模型，可以预测2.19％的广告案件。我们还确定了49个基因，其表达水平与MAC和AD两种表达水平相关。通过途径和过程富集分析，在与广告密切相关的途径或过程中发现这些基因。我们的研究表明，广告可能与阈值超过遗传变异太多。与MAC和特征的相关方法似乎有效地在高效鉴定复杂性状的靶基因鉴定。

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