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首页> 外文期刊>Genomics >Correlation between polymorphisms in IGF2/H19 gene locus and epithelial ovarian cancer risk in Chinese population
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Correlation between polymorphisms in IGF2/H19 gene locus and epithelial ovarian cancer risk in Chinese population

机译：中国人口中IGF2 / H19基因基因遗迹多态性与上皮性卵巢癌风险的相关性

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摘要

To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifically, the minor allele C of rs2525885 and allele A of rs2839698 was associated with elevated EOC genetic susceptibility under both dominant and recessive models (TC?+?CC vs TT: adjusted OR: 1.61, P?=?.031; CC vs TT?+?TC: adjusted OR: 4.87, P?=?.014; GA?+?AA vs GG: adjusted OR: 1.63, P?=?.023; AA vs GG?+?GA: adjusted OR: 2.43, P?=?.007). For rs3741206, the genotype TC?+?CC was associated with a significant decrease in EOC risk with the TT genotype as reference in a dominant genetic model (adjusted OR: 0.44, P?=?.003), while for rs3741219, genotype AA was associated with a 59% decrease in EOC risk only in the recessive model (adjusted OR: 0.41, P?=?.038). In the stratified analysis, an increased risk associated with the variant genotypes was observed in only subjects aged 47?years for rs2525885 (adjusted OR?=?2.04, P?=?.024), rs2839698 (adjusted OR?=?2.50, P?=?.047) and rs3741206 (adjusted OR?=?0.37, P?=?.009), respectively. Whats more, the TC?+?CC genotype of rs2525885 was significantly associated with advanced FIGO stage (III vs II, adjusted OR?=?2.73, P?=?.040).
机译：为了探讨人IGF2 / H19基因遗址和上皮卵巢癌（EOC）风险的SNP之间的关联，我们在422名中进行了病例对照研究（219名患者和203例无癌症对照）。发现有四个SNP（RS2525885，RS2839698，RS3741206，RS3741219）与EOC风险有关。具体地，RS2839698的次要等位基因C和RS2839698的等位基因A与主导和隐性模型（TC？+ΔCCVS TT）下的EoC遗传易感性升高有关（TC？CC VS TT：4.61，P？=Δ.031; CC VS TT ？+ tc：调整或：4.87，p？= ?. 014; ga; ga？+？aa vs gg：调整或：1.63，p？= ?. 023; aa与gg？+？ga：调整或：2.43， p？= 007）。对于RS3741206，基因型Tc？CC与TT基因型在优势遗传模型中的参考有关的大量降低与EoC风险显着降低（调整或：0.44，P？=Δ.003），而GENOTYPE AA在隐性模型中仅与EOC风险减少59％的风险相关联（调整为0.41，p？= 038）。在分层分析中，仅在rs2525885（调整或？2.04，p？= 3.024），Rs2839698（调整或？=Δ=？=Δ=？=？=？=？=？=？=？2.50）中观察到与变体基因型相关的风险增加p？=Δ.047）和RS3741206（调整或？=？0.37，p？=Δ=Δ.009）。更重要的是，TC？+？CC基因型的RS2525885与先进的FIGO阶段显着相关（III VS II，调整或？=？2.73，P ?. 040）。

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