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Identification and validation of immune-related lncRNA prognostic signature for breast cancer

机译：免疫癌症免疫相关LNCRNA预后签名的鉴定及验证

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The prognosis of patients with breast cancer is closely related to both the infiltration of immune cells and the expression of lncRNAs. In this study, we evaluated the infiltration of immune cells in 1109 breast cancer samples obtained from TCGA by applying the ssGSEA to the transcriptome of these samples, thereby generating high immune cell infiltration group and low immune cell infiltration group. On the basis of these groupings, we found 696 differentially expressed lncRNAs which were sequentially subjected to univariate Cox regression and stepwise multiple Cox regression analysis. 11 lncRNAs were identified as prognostic signature for breast cancer. Kaplan-Meier analysis, univariate Cox regression, multivariate Cox regression, and ROC analyses further revealed that this 11-lncRNA signature was a novel and important prognostic factor independent of multiple clinicopathological parameters. The TIMER database showed that this 11-lncRNA prognostic signature for breast cancer was associated with the infiltration of immune cell subtypes.
机译：乳腺癌患者的预后与免疫细胞的渗透和LNCRNA的表达密切相关。在这项研究中，通过将SSGSEA施加到这些样品的转录组中，评估了从TCGA获得的1109乳腺癌样品中免疫细胞的浸润，从而产生高免疫细胞浸润组和低免疫细胞渗透组。在这些分组的基础上，我们发现696次差异表达的LNCRNA，其依次进行单变量COX回归和逐步多元COX回归分析。 11 LNCRNA被鉴定为乳腺癌的预后签名。 Kaplan-Meier分析，单变量Cox回归，多元Cox回归和ROC分析进一步揭示了11-Lncra签名是一种独立于多个临床病理参数的新颖和重要的预后因素。定时器数据库表明，乳腺癌的11-LNCRNA预后签名与免疫细胞亚型的浸润有关。

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