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首页> 外文期刊>Genomics >Diversity analysis at MHC class II DQA locus in buffalo (Bubalus bubalis) indicates extensive duplication and trans-species evolution
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Diversity analysis at MHC class II DQA locus in buffalo (Bubalus bubalis) indicates extensive duplication and trans-species evolution

机译：Buffalo（Bubalus Bubalis）MHC II类DQA基因座的多样性分析表明广泛的重复和跨物种演化

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Variation at MHC Class II-DQA locus in riverine and swamp buffaloes (Bubu) has been explored in this study. Through sequencing of buffalo DQA, 48 nucleotide variants identified from 17 individuals, reporting 42 novel alleles, including one pseudogene. Individual animal displayed two to seven variants, suggesting the presence of more than two Bubu-DQA loci, as an evidence of extensive duplication. dN values were found to be higher than dS values at peptide binding sites, separately for riverine and swamp buffaloes, indicating locus being under positive selection. Evolutionary analysis revealed numerous trans-species polymorphism with alleles from water buffalo assigned to at least three different loci (Bubu-DQA1, DQA2, DQA3). Alleles of both the sub-species intermixed within the cluster, showing convergent evolution of MHC alleles in bovines. The results thus suggest that both riverine and swamp buffaloes share con-current arrangement of DQA region, comparable to cattle in terms of copy number and population polymorphism.
机译：本研究探讨了河流和沼泽地水牛（Bubu）的MHC II-DQA基因座的变异。通过对17个个体确定的48个核苷酸变体的测序，报告了42个新等位基因，包括一个假基因。个体动物显示两到七种变种，表明存在超过两个Bubu-DQA基因座，作为广泛复制的证据。发现DN值高于肽结合位点的DS值，分别用于河流和沼泽水牛，表明位于阳性选择的基因座。进化分析揭示了许多来自分配给至少三种不同基因座（Bubu-DQA1，DQA2，DQA3）的水牛的等位基因的多态性多态性。两种亚种的等位基因在簇内混合，显示牛中MHC等位基因的会聚演化。因此，结果表明，河流和沼泽水牛都共享DQA区域的控制，与拷贝数和人口多态性方面的牛相当。

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