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Effect of Helicobacter pylori Treatment on Long-term Mortality in Patients with Hypertension

机译：<斜体>幽门螺杆菌的影响 - 高血压患者长期死亡率的影响

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Background/Aims A meta-analysis of randomized trials performed in healthy asymptomatic individuals suggested that overall mortality may increase after Helicobacter pylori eradication despite a significant decrease in the gastric cancer incidence and mortality rates. This retrospective population-based cohort study investigated if H. pylori treatment is associated with an increase in overall mortality in patients with hypertension. Methods From the database of the Korean National Health Insurance Sample Cohort, we selected 198,487 patients treated for hypertension between 2002 and 2010. Those who received H. pylori treatment ( H. pylori treatment cohort, 5,541 patients) were matched to those who did not (nontreatment cohort, 11,082 patients) at the ratio of 1 to 2. The primary outcome was the risk of overall mortality. The secondary outcomes were the risks of mortality due to cardiovascular disease, cerebrovascular disease, and cancer. The outcomes were evaluated from 6 months after H. pylori treatment to December 2013. A Cox proportional hazard model was used to estimate the hazard ratios (HRs). Results During a median follow-up period of 4.8 years, death from any cause was reported in 4.1% of the patients in the H. pylori treatment cohort and 5.5% of the patients in the nontreatment cohort. The adjusted HR (aHR) for overall mortality in the H. pylori treatment cohort was 0.70 (95% confidence interval [CI], 0.60 to 0.82; p&0.001). With regard to cause-specific mortality, compared with the nontreatment cohort, the H. pylori treatment cohort had a lower risk of mortality due to cerebrovascular disease (aHR, 0.46; 95% CI, 0.26 to 0.81; p=0.007). The risks of mortality due to cancer and cardiovascular disease were not different between the cohorts. Conclusions H. pylori treatment is not associated with an increase in overall mortality in patients treated for hypertension.
机译：背景/旨在在健康无症状中进行的随机试验的荟萃分析表明，尽管胃癌发病率和死亡率显着降低，但幽门螺杆菌根除术后总体死亡率可能会增加。基于回顾性的人群的队列研究研究了H. Pylori治疗与高血压患者的总体死亡率增加有关。方法从韩国国家健康保险样本队列数据库中选择了198,487名患者，治疗2002年至2010年的高血压患者。那些接受H. Pylori治疗（H. Pylori治疗队列，5,541名患者）的人与那些没有（非收缩队列，11,082名患者的比例为1至2.初级结果是总体死亡率的风险。二次结果是由于心血管疾病，脑血管病和癌症导致的死亡率的风险。从H. Pylori治疗到2013年12月后6个月评估结果。使用Cox比例危害模型来估计危险比（HRS）。结果在4.8岁的中位后续期间，在幽门螺杆菌治疗队的4.1％的患者中报告了任何原因的死亡，患者中的5.5％的患者患者。调整后的HR（AHR）在H.幽门螺杆菌处理队列中的总体死亡率为0.70（置信区间隔95％，0.60至0.82; P <0.001）。关于造成造成的死亡率，与非收发队列相比，H.幽门植物治疗队列由于脑血管疾病（AHR，0.46; 95％CI，0.26至0.81; p = 0.007），死亡风险较低。由于癌症和心血管疾病导致的死亡率的风险在群组之间并不不同。结论H.幽门螺杆菌治疗与高血压治疗患者的总体死亡率的增加无关。

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