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首页> 外文期刊>Food and Nutrition Sciences >Dietary Combination of Fish Oil and Hemoglobin Hydrolysates Alters Serum and Liver Lipid Contents in Rat
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Dietary Combination of Fish Oil and Hemoglobin Hydrolysates Alters Serum and Liver Lipid Contents in Rat

机译：鱼油和血红蛋白的膳食组合水解产物在大鼠中改变血清和肝脂质含量

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Fish oil has been shown to have anti-inflammatory and anti-cancer effects, and to reduce serum triacylglycerol (TAG) levels by stimulating lipid oxidation and inhibiting lipogenesis in the liver. A small number of studies have demonstrated the synergistic effect of fish oil and other bioactive components. This study examined the effect of fish oil in combination with porcine hemoglobin (Hb) hydrolysates on serum and liver lipid contents in rats. Male Wistar rats were divided into four groups; one group was fed a casein and soybean oil-based semi-purified basal diet and other three groups were fed the basal diet supplemented with 2% fish oil, 0.175% Hb hydrolysates, and 2% fish oil plus 0.175% Hb hydrolysates, respectively, for 4 weeks. The fish oil diet decreased serum and liver TAG contents but did not change serum and liver cholesterol levels. The dietary combination of fish oil and Hb hydrolysates decreased serum and liver TAG and cholesterol contents owing to the additive effect of both compounds, and this diet reduced the serum non-high-density lipoprotein cholesterol content as a result of a synergistic effect. This hypolipidemic effect was in part caused by enhanced excretion of fecal fatty acids, neutral steroids, and acidic steroids. The results of this study suggest that the combined intake of fish oil and Hb hydrolysates may play beneficial roles in the prevention of cardiovascular disease as compared with fish oil alone.
机译：已显示鱼油具有抗炎和抗癌作用，并通过刺激脂质氧化和抑制肝脏脂肪生成来减少血清三酰基甘油（标签）水平。少数研究表明了鱼油和其他生物活性成分的协同效应。本研究检测了鱼油与猪血红蛋白（HB）水解产物的血清和肝脂质含量在大鼠中的效果。雄性Wistar大鼠分为四组;一组喂养酪蛋白和豆油基半纯化的基础饮食等三组喂入补充2 ％鱼油，0.175 ％HB水解产物的基础饮食，2 ％鱼油加0.175 ％HB分别水解产物4周。鱼油饮食减少了血清和肝标签含量，但没有改变血清和肝胆水平。由于两种化合物的添加效果，鱼油和Hb水解液的膳食组合降低了血清和肝脏标签和胆固醇含量，并且这种饮食减少了血清非高密度脂蛋白胆固醇含量的增强效应。这种低血脂效应部分是由增强粪便脂肪酸，中性类固醇和酸性类固醇的排泄引起的部分。本研究的结果表明，与单独的鱼油相比，鱼油和HB水解产物的组合摄入可能在预防心血管疾病中起着有益的作用。

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