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首页> 外文期刊>Frontiers in Neuroanatomy >Inner SPACE: 400-Micron Isotropic Resolution MRI of the Human Brain
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Inner SPACE: 400-Micron Isotropic Resolution MRI of the Human Brain

机译：内部空间：人脑的400微米各向同性分辨率

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Objectives Clinically relevant neuroanatomy is challenging to teach, learn and remember since many functionally important structures are visualized best using histology stains from serial 2D planar sections of the brain. In clinical patients, the locations of specific structures then must be inferred from spatial position and surface anatomy. A 3D MRI dataset of neuroanatomy has several advantages including simultaneous multi-planar visualization in the same brain, direct end-user manipulation of the data and image contrast identical to clinical MRI. We created 3D MRI datasets of the postmortem brain with high spatial and contrast resolution for simultaneous multi-planar visualization of complex neuroanatomy. Materials and Methods Whole human brains ( N = 6) were immersion-fixed in 4% formaldehyde for 4 weeks, then washed continuously in water for 48 h. The brains were imaged on a clinical 3-T MRI scanner with a 64-channel head and neck coil using a 3D T2-weighted sequence with 400-micron isotropic resolution (voxel = 0.064 mm ~(3); time = 7 h). Besides resolution, this sequence has multiple adjustments to improve contrast compared to a clinical protocol, including 93% reduced turbo factor and 77% reduced effective echo time. Results This MRI microscopy protocol provided excellent contrast resolution of small nuclei and internal myelinated pathways within the basal ganglia, thalamus, brainstem, and cerebellum. Contrast was sufficient to visualize the presence and variation of horizontal layers in the cerebral cortex. 3D isotropic resolution datasets facilitated simultaneous multi-planar visualization and efficient production of specific tailored oblique image orientations to improve understanding of complex neuroanatomy. Conclusion We created an unlabeled high-resolution digital 3D MRI dataset of neuroanatomy as an online resource for readers to download, manipulate, annotate and use for clinical practice, research, and teaching that is complementary to traditional histology-based atlases. Digital MRI contrast is quantifiable, reproducible across brains and could help validate novel MRI strategies for in vivo structure visualization.
机译：目的临床相关的神经肿瘤是教导，学习和记住的挑战，因为许多功能重要的结构使用大脑的串行2D平面部分使用组织学污渍最佳。在临床患者中，必须从空间位置和表面解剖学推断出特定结构的位置。神经肿瘤的3D MRI数据集具有多种优点，包括同一大脑中的同时多平面可视化，直接最终用户操纵数据和图像对比度与临床MRI相同。我们为淘汰后的3D MRI数据集具有高空间和对比度分辨率，用于同时多平面可视化复杂神经瘤。材料和方法全部人性大脑（n = 6）在4％甲醛中浸渍4周，然后在水中连续洗涤48小时。使用具有400微米各向同性分辨率的3D T2加权序列在临床3-T 2加权序列上与64通道头部和颈部线圈进行成像，使用400微米的各向同性分辨率（voxel = 0.064mm〜（3）;时间= 7小时）。除了分辨率外，该序列与临床方案相比，该序列具有多种调整，以提高对比度，包括93％降低涡轮增压因子和77％的有效回波时间。结果该MRI显微镜协定提供了基础神经节，丘脑，脑干和小脑内的小核和内部肢体型途径的出色对比度分辨率。对比度足以可视化脑皮层中水平层的存在和变化。 3D各向同性分辨率数据集促进了同时多平面可视化和高效生产特定的定制倾斜图像取向，以提高对复杂神经瘤的理解。结论我们创建了一个未标记的高分辨率数字3D MRI数据集，作为读者下载，操纵，注释和用于临床实践，研究和教学的在线资源，这是对基于传统的组织学的地图集的互补。数码MRI对比度是可量化的，在大脑上可重复，可以帮助验证体内结构可视化的新型MRI策略。

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