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首页> 外文期刊>Frontiers in Physiology >Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing
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Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

机译：动态钳位在心律失常研究中的应用：在药物目标发现和安全药理学测试中的作用

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Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacological safety testing. Through the injection of computationally simulated conductances into isolated cardiomyocytes in a real-time continuous loop, dynamic clamp has greatly expanded the capabilities of patch clamp outside traditional static voltage and current protocols. Recent applications include fine manipulation of injected artificial conductances to identify promising drug targets in the prevention of arrhythmia and the direct testing of model-based hypotheses. Furthermore, dynamic clamp has been used to enhance existing experimental models by addressing their intrinsic limitations, which increased predictive power in identifying pro-arrhythmic pharmacological compounds. Here, we review the recent advances of the dynamic clamp technique in cardiac electrophysiology with a focus on its future role in the development of safety testing and discovery of anti-arrhythmic drugs.
机译：动态钳位，用于阐明潜在的心电神经学潜在的潜在的抗心律失常目标和药理学安全测试的有前途的工具，其用于阐明离子机制的混合计算实验技术。通过将计算模拟的电导注射到实时连续循环中的分离的心肌细胞中，动态夹具大大扩展了传统静态电压和电流协议外的膜片钳的能力。最近的应用包括对注射的人工导电的微量操作，以确定预防心律失常和基于模型假设的直接测试的有希望的药物靶标。此外，通过解决其内在限制来增强动态夹具来增强现有的实验模型，这增加了识别前心律失常药理学化合物的预测力。在这里，我们审查了动态钳位技术在心脏电生理学中的最新进展，重点关注其在安全测试和发现抗心律失常药物的未来作用。

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