9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice

Noa Zolberg Relevy; Ralph Rühl; Ayelet Harari; Itamar Grosskopf; Iris Barshack; Ami Ben-Amotz; Uri Nir; Hugo Gottlieb; Yehuda Kamari; Dror Harats; Aviv Shaish

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9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice

机译：9-CISβ-胡萝卜素抑制女性LDLR - / - 小鼠的动脉粥样硬化发育

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Background: Several epidemiological studies have shown that diets rich in carotenoids are associated with a reduced risk of cardiovascular disease. However, administration of synthetic all-trans b-carotene was reported to have no effect on cardiovascular disease. We previously showed that the 9-cis b-carotene-rich powder of the alga Dunaliella bardawil inhibits atherogenesis and reduces plasma non-HDL cholesterol levels in mice.

机译：背景：几项流行病学研究表明，富含类胡萝卜素的饮食与心血管疾病的风险降低有关。然而，据报道，合成全反式B-胡萝卜素的给药对心血管疾病没有影响。我们以前表明，富含藻氏菌的9-CIS B-CAROTENE的粉末抑制了血液发生，并减少小鼠中的血浆非HDL胆固醇水平。

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《Functional Foods In Health And Disease》 |2015年第2期|共13页
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Noa Zolberg Relevy; Ralph Rühl; Ayelet Harari; Itamar Grosskopf; Iris Barshack; Ami Ben-Amotz; Uri Nir; Hugo Gottlieb; Yehuda Kamari; Dror Harats; Aviv Shaish;
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1. A 9-cis β-Carotene–Enriched Diet Inhibits Atherogenesis and Fatty Liver Formation in LDL Receptor Knockout Mice1,2 [J] . Ayelet Harari358 Dror Harats358 Daniella Marko35 Hofit Cohen35 Iris Barshack4 Yehuda Kamari35 Ayelet Gonen3 Yariv Gerber56 Ami Ben-Amotz7 and Aviv Shaish3* The Journal of Nutrition . 2008,第10期

机译：富含9-顺式β-胡萝卜素的饮食抑制LDL受体基因敲除小鼠1,2的动脉粥样硬化和脂肪肝形成1,2
2. A 9-cis β-Carotene–Enriched Diet Inhibits Atherogenesis and Fatty Liver Formation in LDL Receptor Knockout Mice [J] . Ayelet Harari358, Dror Harats358, Daniella Marko35, The Journal of Nutrition: Official Organ of the American Institute of Nutrition . 2008,第10期

机译：富含9-顺式β-胡萝卜素的饮食可抑制LDL受体基因敲除小鼠的动脉粥样硬化和脂肪肝形成。
3. Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr-/- mice with diet-induced insulin resistance [J] . Molecular Nutrition and Food Research . 2017,第4期

机译：缓解VLDL产量是Laponaria japonica多糖的重要机制，抑制LDLR - / - 小鼠的动脉粥样硬化，饮食诱导的胰岛素抵抗力
4. The role of experimental model of atherosclerosis: apoE-knockout mice in developing new drugs against atherosclerosis [C] . Jawien J. International Congress on Coronary Artery Disease. . 2013

机译：动脉粥样硬化的实验模型的作用：Apoe-Nockout小鼠在制育新药物对动脉粥样硬化的作用
5. The chemopreventive effects of 9-cis retinoic acid and 1alpha-25-dihydroxyvitamin D3 against NNK-induced lung carcinogenesis in A/J mice. [D] . Mernitz, Heather. 2006

机译：9-顺式视黄酸和1alpha-25-二羟基维生素D3对NNK诱导的A / J小鼠肺癌发生的化学预防作用。
6. The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR-/- mice [O] . Binglin Li, Xin Lu, Jia Wang, 2018

机译：P-选择蛋白糖蛋白配体-1（PSGL-1）缺乏抑制LDLR-/-小鼠动脉粥样硬化进展的代谢组学研究
7. 9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice [O] . Noa Zolberg Relevy, Ralph Rühl, Ayelet Harari, 2015

机译：9-CISβ-胡萝卜素抑制女性LDLR - / - 小鼠的动脉粥样硬化发育

9-cis β-carotene Inhibits Atherosclerosis Development in Female LDLR-/- Mice

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