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Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling

机译:姜黄和中国金三甲协同抑制前列腺癌细胞增殖和NF-KB信号传导

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Background: Pre-clinical studies using bioactive compounds from botanicals appear to offer some protection against cancer. Research using single bioactives contributes greatly to our understanding of their mechanism of action, but in vitro?studies demand concentrations that are higher than achievable in humans (μM). However, maintaining these bioactives in the presence of other compounds originally derived from the food or extract of origin may synergistically lower the bioactive dose so translatability becomes feasible. The objective of this study was to determine if bio-efficacy of phytonutrients can be enhanced when used in combination even at doses that are ineffective for any compound when used in isolation.
机译:背景:使用来自植物学的生物活性化合物的临床前研究似乎为癌症提供了一些保护。使用单一生物术争的研究大大促进了我们对其行动机制的理解,而是在体外呢?研究需求浓度高于人类(μm)的浓度。然而,在最初来自食物或原产地衍生的其他化合物的情况下保持这些生物术可能协同降低生物活性剂量,使得可移性变得可行。本研究的目的是确定植物营养素的生物效果是否可以在甚至在用于分离使用时为任何化合物无效的剂量使用时增强。

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