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首页> 外文期刊>Malaria Journal >Experimental hut evaluation of a novel long-lasting non-pyrethroid durable wall lining for control of pyrethroid-resistant Anopheles gambiae and Anopheles funestus in Tanzania
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Experimental hut evaluation of a novel long-lasting non-pyrethroid durable wall lining for control of pyrethroid-resistant Anopheles gambiae and Anopheles funestus in Tanzania

机译：一种新型长持久的非拟除虫菊酯耐用壁衬里的实验性小屋评价，用于控制拟菌抗虫的杀螨剂冈比亚和坦桑尼亚的吞咽饲料

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BackgroundA novel, insecticide-treated, durable wall lining (ITWL), which mimics indoor residual spraying (IRS), has been developed to provide prolonged vector control when fixed to the inner walls of houses. PermaNet? ITWL is a polypropylene material containing non-pyrethroids (abamectin and fenpyroximate) which migrate gradually to the surface. MethodsAn experimental hut trial was conducted in an area of pyrethroid-resistant Anopheles gambiae s.l. and Anopheles funestus s.s. to compare the efficacy of non-pyrethroid ITWL, long-lasting insecticidal nets (LLIN) (Interceptor?), pyrethroid ITWL (ZeroVector?), and non-pyrethroid ITWL?+?LLIN. ResultsThe non-pyrethroid ITWL produced relatively low levels of mortality, between 40–50% for An. funestus and An. gambiae , across all treatments. Against An. funestus , the non-pyrethroid ITWL when used without LLIN produced 47% mortality but this level of mortality was not significantly different to that of the LLIN alone (29%, P?=?0.306) or ITWL?+?LLIN (35%, P?=?0.385). Mortality levels for An. gambiae were similar to An. funestus with non-pyrethroid ITWL, producing 43% mortality compared with 26% for the LLIN. Exiting rates from ITWL huts were similar to the control and highest when the LLIN was present. An attempt to restrict mosquito access by covering the eave gap with ITWL (one eave open vs four open) had no effect on numbers entering. The LLIN provided personal protection when added to the ITWL with only 30% blood-fed compared with 69 and 56% (P?=?0.001) for ITWL alone. Cone bioassays on ITWL with 30?min exposure after the trial produced mortality of?>90% using field An. gambiae. ConclusionsDespite high mortality in bioassays, the hut trial produced only limited mortality which was attributed to pyrethroid resistance against the pyrethroid ITWL and low efficacy in the non-pyrethroid ITWL. Hut ceilings were left uncovered and may have served as a potential untreated refuge. By analogy to IRS campaigns, which also do not routinely treat ceilings, high community coverage with ITWL may still reduce malaria transmission. Restriction of eave gaps by 75% proved an inadequate barrier to mosquito entry. The findings represent the first 2?months after installation and do not necessarily predict long-term efficacy.
机译：背景，已经开发了模拟室内剩余喷涂（IRS）的新型杀虫剂处理的耐用壁衬（ITWL），以在固定到房屋内壁时提供长时间的矢量控制。 ITWL是含有非拟肽（Abamectin和Fenpyrois）的聚丙烯材料，其逐渐迁移到表面上的聚丙烯材料。方法在拟除虫菊酯抗鼠冈比亚S.L的面积中进行实验小屋试验。和anopheles funestuss。比较非拟除虫菊酯ITWL，长持久的杀虫网（Llin）（拦截剂β），拟除虫菊虫ITWL（Zerovector β），以及非拟除虫菊酯ITWL？ +？llin。结果，非拟除虫菊酯ITWL产生的死亡率相对较低，40-50％之间。殡仪馆和一个。冈比亚，在所有治疗中。反对。 Finestus，非拟除虫菊酯ITWL在没有Llin的情况下产生的死亡率为47％，但这种死亡率与Llin单独没有显着差异（29％，P？0.306）或ITWL？+？Llin（35％， p？=？0.385）。死亡率。冈比亚类似于一个。具有非拟除虫菊酯ITWL的猪，产生43％的死亡率，而Llin为26％。当Llin存在时，ITWL HUTS的退出率类似于控制和最高。尝试通过用ITWL覆盖EAVE间隙（一个EAVE OPEN VS四个开放）来限制蚊子访问没有对数字的影响没有影响。当单独为ITWL添加到69和56％（P？= 0.001）时，Llin为ITWL添加到ITWL时提供了个人保护。在试验后，锥形生物测量在ITWL上有30次曝光，使用田间产生的死亡率？> 90％。冈比亚。结论生物测定中的高死亡率，小屋试验仅产生有限的死亡率，这些死亡率仅归因于拟除虫菊酯ITWL的拟除虫菊酯抗性，并且在非拟除虫菊酯ITWL中的低功效。小屋未覆盖，可能是潜在的未经治疗的避难所。通过类比IRS运动，这也不经常治疗天花板，高社区覆盖率与ITWL仍可能减少疟疾传播。 75％的EAVE间隙的限制证明了蚊帐的障碍不足。该研究结果代表了前2个月的安装后数月，不一定预测长期疗效。

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