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首页> 外文期刊>Frontiers in Cell and Developmental Biology >A Review of Precision Oncology Knowledgebases for Determining the Clinical Actionability of Genetic Variants
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A Review of Precision Oncology Knowledgebases for Determining the Clinical Actionability of Genetic Variants

机译：确定遗传变异临床可诉性的精密肿瘤学知识产作综述

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The increased availability of tumor genetic testing and targeted cancer therapies contributes to the advancement of precision medicine in the field of oncology. Precision oncology knowledgebases provide a way of organizing clinically relevant genetic information in a way that is easily accessible for both oncologists and patients, facilitating the genetic-based clinical decision making. Many organizations and companies have built precision oncology knowledgebases, intended for multiple users. In general, these knowledgebases offer information on cancer-related genetic variants as well as their associated diagnostic, prognostic, and therapeutic implications, but they often differ in their information curations, designs, and user experiences. It is advisable that oncologists use multiple knowledgebases during their practice to have them complement each other. In the future, convergence towards common standards and formats is needed to ensure that the comprehensive knowledge across all sources can be unified to bring the oncology community closer to the achievement of the goal of precision oncology.
机译：肿瘤遗传学检测和靶向癌症疗法的增加有助于肿瘤学领域的精确药物的进步。精密肿瘤学知识库提供一种以易于访问的方式组织临床相关的遗传信息，促进基于遗传的临床决策。许多组织和公司建立了精密肿瘤学知识库，适用于多个用户。通常，这些知识库提供有关癌症相关的遗传变异的信息以及它们相关的诊断，预后和治疗意义，但它们通常在其信息策苗，设计和用户体验中不同。建议肿瘤学家在他们的练习期间使用多个知识库，使它们相互补充。未来，需要融合共同标准和格式，以确保所有来源的全面知识可以统一，以使肿瘤学区更接近实现精密肿瘤的目标。

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