• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Frontiers in Pharmacology >Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice
【24h】

Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice

机译：<斜视>薄荷醇和薄荷酮和薄膜 - 与乙酰胱氨酸酸相关，及其与<斜视>血吸虫麦森感染的小鼠的肝纤维化的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Schistosomiasis is an important parasitic disease caused by Schistosoma mansoni , an intravascular trematode. Schistosomiasis treatment is limited to just one drug, Praziquantel (PZQ). Thus, studies on new antischistosomal compounds are of fundamental importance to disease control. Here we report on the effects of Mentha piperita L. compounds – menthol and menthone – in association with acetylsalicylic acid (ASA) in the regulation of hepatic fibrosis caused by schistosomiasis granulomas. Six different groups of Swiss rats were infected with 80 cercariae. Two groups received only menthol and menthol treatment at different concentrations (30 and 50 mg/kg); two groups received treatment with the same concentration of menthol and menthol, but associated the ASA. All groups received treatment for 14 consecutive days from the 35 days after the parasitic infection. In addition, three other groups were used: uninfected and untreated group, infected and untreated group and infected group treated with the commercial drug (single dose). Parasitological, cytological and histological analyses were performed. Results showed a significant reduction on the number of eosinophils found in the peritoneal cavity lavage (LPC) in all treated groups and on the number of eosinophils found in the blood of PZQ treated group, in the blood of the group treated with 30 mg/kg of Mentaliv~(?)and in the blood of group treated with 50 mg/kg Mentaliv~(?)+ ASA when compared to the infected group. All treated groups presented a reduction in the parasite load, represented by the number of S. mansoni eggs, in the experimental group treated with 30 mg/kg of menthol and menthone a 62.80% reduction was observed and in the experimental group treated with 50 mg/kg of menthol and menthone + ASA a reduction of 64.21% was observed. In the liver histological analysis we observed that all Mentaliv~(?)treated groups expressed a unique cytological profile, with diffused cells through the granuloma. In the experimental group treated with 50 mg/kg of Mentaliv~(?)+ ASA it was possible to observe the formation of type III collagen fibers, a typical wound healing characteristic. Our data strongly suggest that both the hepatic fibrosis and the inflammatory process were regulated through the schistosomiasis granulomatous process after treatment with menthol and menthone associated with ASA.
机译：血吸虫病是一种重要的寄生疾病，由Schistosoma Mansoni，血管内震颤引起。血吸虫病治疗仅限于一种药物，吡喹酮（PZQ）。因此，对新的抗血栓药物化合物的研究对疾病控制具有根本的重要性。在这里，我们报告了薄荷哌塔L.化合物 - 薄荷醇和晶体酮与乙酰胱氨酸（ASA）的影响报告了血吸虫病造粒虫引起的肝纤维化调节中的乙酰胱氨酸（ASA）。六只不同群体瑞士大鼠被80种Cercariae感染。两组仅接受薄荷醇和薄荷醇处理不同浓度（30和50mg / kg）;两组接受了具有相同浓度的薄荷醇和薄荷醇的治疗，但是相关的ASA。所有群体在寄生感染后35天连续14天接受治疗。此外，使用了三个其他群体：用商业药物（单剂量）处理未感染和未经处理的基团，感染和未处理的组和感染的组。进行寄生学，细胞学和组织学分析。结果表明，在所有治疗组的腹膜腔灌洗（LPC）中发现的嗜酸性粒细胞数目和在PZQ处理组血液中发现的嗜酸性粒细胞的数量，在用30mg / kg处理的血液中Mentaliv〜（？）和在与感染的组相比时用50mg / kg Mentaliv〜（？）+ Asa治疗的血液中。所有治疗组织均寄生载量减少了由麦酮蛋数表示的寄生虫载荷，在用30mg / kg薄荷醇治疗的实验组中，观察到62.80％的减少62.80％，并在用50毫克处理的实验组中进行62.80％ / kg薄荷醇和薄荷酮+ asa减少了64.21％。在肝脏组织学分析中，我们观察到所有的Mentaliv〜（？）处理基团表达了一种独特的细胞学曲线，通过肉芽肿具有扩散细胞。在用50mg / kg苗〜（α）+ Asa处理的实验组中，可以观察II型胶原纤维的形成，典型的伤口愈合特性。我们的数据强烈表明，肝纤维化和炎症过程均通过血吸虫和与ASA相关的薄荷醇和晶体酮进行处理后通过血吸虫病肉芽肿法调节。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号