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首页> 外文期刊>Mayo Clinic Proceedings: Innovations, Quality & Outcomes >More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia
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More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia

机译：与其他肺炎相比，急性Covid-19肺炎中更严重的高凝态

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Objective To conduct a comprehensive evaluation of coagulation profiles—via traditional and whole blood thromboelastometry tests—in coronavirus disease 2019 (COVID-19)–positive vs COVID-19–negative patients admitted to medical wards for acute pneumonia. Patients and Methods We enrolled all consecutive patients admitted to internal medicine wards of Padova University Hospital between 7 March and 30 April, 2020, for COVID-19–related pneumonia (cases) vs non–COVID-19 pneumonia (controls). A group of healthy individuals acted as baseline for thromboelastometry parameters. Results Fifty-six cases (mean age, 64±15 years; male/female, 37/19) and 56 controls (mean age, 76±11 years; male/female, 35/21) were enrolled. Cases and controls exhibited markedly hypercoagulable thromboelastometry profiles vs healthy individuals, mainly characterized by a significantly shorter propagation phase of coagulation (clot formation time) and significantly increased maximum clot firmness ( P .001 for all comparisons). Patients with COVID-19 pneumonia had significantly shorter clot formation time and higher maximum clot firmness ( P .01 and P .05, respectively, for all comparisons) than did controls. Conclusion Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself.
机译：目的旨在通过传统和全血血管弹性测定术治疗冠状病毒疾病（Covid-19） - 急性肺炎治疗病房的传统和全血血管血管术检测 - 通过传统和全血血管血管血管术检测。患者和方法我们招收到2020年4月7日至4月30日之间的帕多瓦大学医院内科病房的所有连续患者，用于Covid-19相关肺炎（病例）与非Covid-19肺炎（控制）。一群健康个体担任血栓弹性测定参数的基线。结果56例病例（平均年龄，64±15岁;男性/女，37/19）和56个对照（平均年龄，76±11年;男/女，35/21）均已注册。病例和对照表现出明显高凝血的血栓放射测定曲线与健康个体，主要是凝固（凝块形成时间）的显着较短的传播阶段，并且显着增加了最大凝块坚固度（所有比较的P <.001）。患有Covid-19肺炎的患者显着缩短了凝块形成时间和更高的最大凝块固定性（P <.01和P <.05，所有比较分别用于所有比较）而不是控制。结论患者患有Covid-19肺炎的内科病房的患者呈现出明显的普发形成状态，似乎是Covid-19而不是肺炎本身。

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