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首页> 外文期刊>Frontiers in Genetics >Detection and Comparative Analysis of Methylomic Biomarkers of Rheumatoid Arthritis
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Detection and Comparative Analysis of Methylomic Biomarkers of Rheumatoid Arthritis

机译：类风湿性关节炎甲基科生物标志物的检测与对比分析

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Rheumatoid arthritis (RA) is a common autoimmune disorder influenced by both genetic and environmental factors. To investigate possible contributions of DNA methylation to the etiology of RA with minimum confounding genetic heterogeneity, we investigated genome-wide DNA methylation in disease-discordant monozygotic twin pairs. This study hypothesized that methylomic biomarkers might facilitate accurate RA detection. A comprehensive series of biomarker detection algorithms were utilized to find the best methylomic biomarkers for detecting RA patients using the methylomic data of the peripheral blood samples. The best model achieved 100.00% in accuracy (Acc) with 81 methylomic biomarkers and a 10-fold cross-validation (10FCV) strategy. Some of the methylomic biomarkers were experimentally confirmed to be associated with the onset or development of RA. It is also interesting to observe that many of the detected biomarkers were from chromosome Y, supporting the knowledge that RA has a significant gender discrepancy.
机译：类风湿性关节炎（RA）是受遗传和环境因素影响的常见自身免疫性疾病。为了研究DNA甲基化对Ra的病因的可能贡献，具有最小的混淆遗传异质性，我们研究了疾病 - 不排名间的单义根双对中的全基因组DNA甲基化。这项研究假设甲基麦克科生物标志物可以促进准确的RA检测。利用全面的一系列生物标记检测算法，用于使用外周血样品的甲基族数据来检测RA患者的最佳甲基MIOM标志物。最佳型号可实现100.00％的精度（ACC），具有81个甲基MIOM标志物和10倍的交叉验证（10FCV）策略。实验证实，一些甲基MIOM标志物与RA的发作或发育相关。观察到许多检测到的生物标志物也来自染色体Y，支持RA具有重要性别差异的知识。

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