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首页> 外文期刊>Frontiers in Human Neuroscience >Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat
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Yoga, Meditation and Mind-Body Health: Increased BDNF, Cortisol Awakening Response, and Altered Inflammatory Marker Expression after a 3-Month Yoga and Meditation Retreat

机译：瑜伽，冥想和思维身体健康：增加BDNF，皮质醇唤醒反应，并在3个月的瑜伽和冥想后恢复后改变炎症标志物表达

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Thirty-eight individuals (mean age: 34.8 years old) participating in a 3-month yoga and meditation retreat were assessed before and after the intervention for psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, and pro- and anti-inflammatory cytokines. Participation in the retreat was found to be associated with decreases in self-reported anxiety and depression as well as increases in mindfulness. As hypothesized, increases in the plasma levels of BDNF and increases in the magnitude of the cortisol awakening response (CAR) were also observed. The normalized change in BDNF levels was inversely correlated with BSI-18 anxiety scores at both the pre-retreat (r = 0.40, p < 0.05) and post-retreat (r = 0.52, p < 0.005) such that those with greater anxiety scores tended to exhibit smaller pre- to post-retreat increases in plasma BDNF levels. In line with a hypothesized decrease in inflammatory processes resulting from the yoga and meditation practices, we found that the plasma level of the anti-inflammatory cytokine Interleukin-10 was increased and the pro-inflammatory cytokine Interleukin-12 was reduced after the retreat. Contrary to our initial hypotheses, plasma levels of other pro-inflammatory cytokines, including Interferon Gamma (IFN-γ), Tumor Necrosis Factor (TNF-α), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) were increased after the retreat. Given evidence from previous studies of the positive effects of meditative practices on mental fitness, autonomic homeostasis and inflammatory status, we hypothesize that these findings are related to the meditative practices throughout the retreat; however, some of the observed changes may also be related to other aspects of the retreat such as physical exercise-related components of the yoga practice and diet. We hypothesize that the patterns of change observed here reflect mind-body integration and well-being. The increased BDNF levels observed is a potential mediator between meditative practices and brain health, the increased CAR is likely a reflection of increased dynamic physiological arousal, and the relationship of the dual enhancement of pro- and anti-inflammatory cytokine changes to healthy immunologic functioning is discussed.
机译：在治疗心理测量措施的干预之前和之后，在脑干源性神经营养因子（BDNF），昼夜唾液皮质醇水平和亲和力之前和以下八个人（意思是年龄：34.8岁）参加3个月的瑜伽和冥想静态的思考，脑源性神经营养因素（BDNF），昼夜唾液皮质醇水平和亲抗炎细胞因子。发现撤退的参与有与自我报告的焦虑和抑郁症的减少以及令人增加的增加。如假设，还观察到增加BDNF的血浆水平并增加皮质醇唤醒反应（汽车）的幅度增加。 BDNF水平的正常化变化与预撤退（R = 0.40，P <0.05）和后退（R = 0.52，P <0.005）的BSI-18焦虑分数与焦虑分数更大的人倾向于在血浆BDNF水平上的后退前较小。根据瑜伽和冥想实践所产生的炎症过程的假设减少，我们发现抗炎细胞因子白细胞介素-10的等离子体水平增加，在后退后，促炎细胞因子白细胞介素-12降低。与我们的初始假设相反，其他促炎细胞因子的血浆水平，包括干扰素γ（IFN-γ），肿瘤坏死因子（TNF-α），白细胞介素-1β（IL-1β），白细胞介素-6（IL-6）在撤退后，白细胞介素-8（IL-8）增加。鉴于先前研究冥想实践对心理健康，自主稳态和炎症地位的积极影响的证据，我们假设这些发现与整个撤退的冥想实践有关;然而，一些观察到的变化也可能与退却的其他方面有关，例如瑜伽实践和饮食的体育锻炼相关组成部分。我们假设观察到的变革模式反映了思想身体整合和福祉。观察到的BDNF水平增加是冥想实践和脑健康之间的潜在调解员，增加的车辆可能反映了增加的动态生理唤起，以及双重增强对健康免疫功能的抗炎细胞因子变化的关系的关系讨论。

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