• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medical Sciences >Cumulative Effects of Low-Level Lead Exposure and Chronic Physiological Stress on Hepatic Dysfunction—A Preliminary Study
【24h】

Cumulative Effects of Low-Level Lead Exposure and Chronic Physiological Stress on Hepatic Dysfunction—A Preliminary Study

机译：低水平铅暴露和慢性生理胁迫对肝功能障碍的累积影响 - 初步研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic physiological stress and hepatic injury were explored in this cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Lead exposure was measured using Blood Lead Levels (BLL), which were divided into quartiles of exposure based on the distribution within the database. Allostatic load (AL), a variable representing chronic physiological stress, was operationalized using ten clinical markers. The geometric mean values for markers of liver injury of interest (a) Aspartate Aminotransferase (AST), (b) Alanine Aminotransferase (ALT), (c) Alkaline Phosphatase (ALP), and (d) Gamma glutamyl-transferase (GGT) were explored in quartiles of lead exposure. Associations between AL and AST, ALT, ALP, and GGT among those exposed to lead were analyzed using linear regression models. In examining lead exposure in increasing quartiles, the geometric mean of the liver injury markers showed significant elevations as lead exposure levels increased. Simple linear regression revealed AL was positively associated with several markers of hepatic injury in all degrees of lead exposure. This study demonstrates the potential dangers of social and environmental exposures to liver health.
机译：使用来自国家卫生和营养考试调查（Nhanes）2007-2010的数据，在这种横断面研究中探讨了慢性生理胁迫和肝损伤。使用血铅水平（BL1）测量铅暴露，其基于数据库内的分布分为曝光的四分位数。 amantutatic载荷（Al），代表慢性生理应激的可变，使用十个临床标记进行操作。感兴趣的肝损伤标记的几何平均值（A）天冬氨酸氨基转移酶（AST），（B）丙氨酸氨基转移酶（ALT），（C）碱性磷酸酶（ALP），和（D）γ谷氨酸转移酶（GGT）是在铅曝光的四分位数中探索。使用线性回归模型分析了Al和Ast，AST，ALT，ALP和GGT之间的关联。在检查增加四分位数中的铅暴露时，随着铅暴露水平增加，肝损伤标记物的几何平均值显示出显着的升高。简单的线性回归显示Al与所有铅暴露的肝损伤的几个标记呈正相关。本研究表明，社会和环境暴露对肝脏健康的潜在危害。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号