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Multiple cerebral microbleeds and atypical β-amyloid deposits: A case report

机译：多发性微杂种和非典型β-淀粉样沉积：案例报告

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Rationale: Cerebral microbleeds are increasingly recognized in various neurological disorders such as cerebral amyloid angiopathy (CAA), Alzheimer disease, and stroke. The presence and number of cerebral microbleeds are known to be independent predictors of cognitive impairment . Patient concerns: A 73-year-old woman visited our memory disorder clinic complaining of progressive memory impairment, which started 2 years ago. Diagnoses: The patient had innumerable cortical/subcortical cerebral microbleeds in the entire brain. We diagnosed the patient with amnestic mild cognitive impairment due to CAA. Interestingly, only focal β-amyloid deposits at the bilateral parietal cortices were seen on amyloid positron emission tomography (PET) scan. Interventions: We have observed changes in her cognitive function without any medication. Outcomes: The cognitive function of the patient was unchanged during the follow-up period. Lessons: Our case was interesting in a few aspects, including the number of cerebral microbleeds and the atypical β- amyloid deposition pattern on amyloid PET scan. Further studies on more cases are needed to evaluate β-amyloid burden and distribution patterns in CAA.
机译：理由：在各种神经系统疾病（如脑淀粉样血管病（CAA），阿尔茨海默病和中风等各种神经系统疾病中越来越识别脑微比物。已知脑微斑块的存在和数量是认知障碍的独立预测因子。病人担忧：一名73岁的女性参观了我们2年前开始的渐进内存障碍的记忆障碍诊所。诊断：患者在整个大脑中具有无数皮质/皮质脑微微肌肤。由于CAA，我们诊断出患有Amnestic认知障碍的患者。有趣的是，在淀粉样态正电子发射断层扫描（PET）扫描上仅观察到双侧耳廓皮质的焦点β-淀粉样沉积物。干预措施：我们观察了未经任何药物的认知功能的变化。结果：在随访期间，患者的认知功能不变。课程：我们的案例在几个方面有趣，包括脑微微型和淀粉样蛋白PET扫描上的非典型β-淀粉样蛋白沉积图案。需要进一步研究更多案例来评估CAA中的β-淀粉样脂和分布图案。

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