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首页> 外文期刊>Medicine. >Bilateral ovarian granulocytic sarcoma as the primary manifestation of acute myelogenous leukemia treated with allogenic stem cell transplantation: A case report
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Bilateral ovarian granulocytic sarcoma as the primary manifestation of acute myelogenous leukemia treated with allogenic stem cell transplantation: A case report

机译：双侧卵巢粒细胞肉瘤作为急性髓性白血病的主要表现，用同种异体干细胞移植治疗：案例报告

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Rationale: Granulocytic sarcoma (GS), also known as chloroma, is a tumor comprising myeloblasts or monoblasts, potentially occurring as an extramedullary mass. Systemic chemotherapy should be used to induce complete remission. However, such patients with chloroma have a poorer treatment outcome than those without extramedullary myeloid sarcomas. Patient concerns: A 30-year-old woman who initially presented with bilateral ovarian masses and splenomegaly was admitted to hospital. Also, her complete blood cell counts showed pancytopenia and blood smear revealed a few immature cells (3%). Diagnoses: A bone marrow biopsy demonstrated acute myelomonocytic leukemia, and the chromosomal analysis revealed a 46, XX, del18 (p11) [20] karyotype and cytogenetics and molecular markers showed all negative results. Interventions: Since this diagnosis, she received remission-inducing chemotherapy comprising anthracycline and cytarabine, which is a standard regimen for acute myeloid leukemia (AML), and followed by allogenic hematopoietic stem cell transplantation from Human leukocyte antigen (HLA)-identical sibling donor. Outcomes: After transplantation, the bone marrow engrafted successfully without complications. She visited our clinic regularly with no evidence of leukemia relapse or graft-versus host disease. Lessons: This report represents the first case of ovarian GS, wherein treatment was successful with high-dose chemotherapy, followed by allogenic hematopoietic stem cell transplantation without oophorectomy.
机译：理由：肉芽细胞肉瘤（GS），也称为胰萎缩，是包含髓细胞或单卵细胞的肿瘤，潜在地作为髓质质量发生。全身化疗应用于诱导完全缓解。然而，这些氯幼的患者具有较差的治疗结果，而不是那些没有髓外肉瘤的治疗结果。患者担忧：最初呈现双边卵巢肿块和脾肿大的30岁女性被入境。此外，她的完全血细胞计数表现出韧皮细胞增生，血液涂片显示出一些未成熟的细胞（3％）。诊断：骨髓活检显示急性骨髓细胞白血病，染色体分析显示出46，XX，DEL18（P11）[20]核型和细胞遗传学和分子标记显示所有阴性结果。干预：自该诊断以来，她接受了包含蒽环类和溶氨酸含量的缓解化疗，这是急性髓性白血病（AML）的标准方案，然后是来自人白细胞抗原（HLA）鉴别的兄弟提供者的同种异体造血干细胞移植。结果：移植后，骨髓成功植入而无需并发症。她定期访问了我们的诊所，没有白血病复发或移植物与宿主病的证据。课程：该报告代表卵巢GS的第一种情况，其中治疗成功，高剂量化疗，其次是同种异体造血干细胞移植而没有oophorectomy。

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