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Systematic review and meta-analysis of whether cesarean section contributes to the incidence of allergic diseases in children: A protocol for systematic review and meta analysis

机译：剖宫产段是否有助于儿童过敏性疾病发病率的系统评价和荟萃分析：系统审查和META分析的议定书

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Background: As abundant evidence shows the composition of gut flora in children born by caesarean section is different from that of vaginal delivery children , studies on whether caesarean section would increase the offspring's risk of developing allergic disease attract extensive attention. However, the results of different researches are inconsistent. Therefore we conduct a systematic review and meta-analysis to explore the relationship between caesarean section and childhood allergic disease. Methods: The protocol followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. Cohort studies for investigating the relationship between caesarean section and the risk of childhood allergic disease will be searched in 4 main databases (PubMed, EMBASE, the Cochrane Library, and the web of science). In addition, a manual search of the references of relevant published studies will also be considered. Four common allergic outcomes will be included: asthma, allergic rhinitis, food allergy , and atopic dermatitis. Studies selection, data extraction, and risk of bias assessment will be conducted by 2 independent reviewers. The primary outcome is the incidence of 4 allergic diseases. Results: The results will provide useful information on whether caesarean section contributes to the increase of allergic disease in children . Conclusion: The findings of this study will be published in a peer-reviewed journal. PROSPERO registration number: CRD42019135196.
机译：背景：充实的证据表明，凯撒部分出生的儿童组成与阴道产后儿童的组成不同，研究剖腹产是否会增加后代的开发过敏性疾病的风险引起广泛的关注。然而，不同研究的结果是不一致的。因此，我们进行系统审查和荟萃分析，探讨剖腹产和儿童过敏性疾病之间的关系。方法：该协议遵循的首选报告项目，用于系统评价和荟萃分析协议。研究队列研究的研究和儿童过敏性疾病风险的研究将在4个主要数据库中搜索（PubMed，Embase，Cochrane图书馆和科学网络）。此外，还将考虑手动搜索相关公开研究的参考文献。将包括四种常见的过敏性结果：哮喘，过敏性鼻炎，食物过敏和特应性皮炎。研究选择，数据提取和偏见评估的风险将由2名独立审稿人进行。主要结果是4例过敏性疾病的发生率。结果：结果将提供有关剖腹产是否有助于增加儿童过敏性疾病的有用信息。结论：本研究的调查结果将在同行评审日期刊上发表。 Prospero注册号：CRD42019135196。

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