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Helicobacter pylori and gastrointestinal and neurological diseases: Study protocol of an umbrella review of systematic reviews and meta-analyses

机译：幽门螺杆菌和胃肠道和神经疾病：系统评价和荟萃分析伞的研究方案

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Background: Systematic reviews showed that Helicobacter pylori (HP) infection is a major risk for developing gastric cancer and gastric ulcer and that it might be the cause of inflammatory bowel diseases, functional gastrointestinal disorders, and neurological diseases like Alzheimer disease. However, the robustness of the evidence was not tested. We will perform an umbrella review to systematically evaluate current evidence on the correlation between HP infection and gastrointestinal and neurological diseases . Methods: We will search OVID MEDLINE, EMBASE, and the Cochrane library for systematic reviews that evaluate the correlation of HP with gastrointestinal and neurological diseases , from inception to 1 July, 2019. Two reviewers will independently screen titles and abstracts of retrieved articles for eligible studies, and they will extract information for data analysis. We will assess heterogeneity between studies using I 2 statistics and evaluate small-study effect in each systematic review through Egger test. Excess significance bias will be evaluated by compared the expected number of clinical studies with positive findings with the observed number. Quality of each systematic review will be assessed by using AMSTAR2 checklist. Ethics and dissemination: This umbrella review is anticipated to be finished in December 2019, and the results will be published in a peer-reviewed journal and disseminated through conference presentation or poster. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval.
机译：背景：系统评论表明，幽门螺杆菌（HP）感染是一种发育胃癌和胃溃疡的主要风险，并且它可能是炎症肠疾病，功能性胃肠疾病和阿尔茨海默病等神经疾病的原因。但是，证据的稳健性没有测试。我们将进行伞审查以系统地评估有关HP感染和胃肠道和神经疾病之间相关性的现有证据。方法：我们将搜索Ovid Medline，Embase和Cochrane文库进行系统性评论，从2019年7月1日开始评估HP与胃肠道和神经系统疾病的相关性。两位审稿人将独立屏幕和摘要的检索物品的标题和摘要研究，他们将提取数据分析的信息。我们将评估使用I 2统计学的研究之间的异质性，并通过Egger测试评估每个系统审查中的小型研究效果。通过将预期的临床研究与观察到的数量进行阳性结果进行了预期的临床研究，评估了过度的显着性偏差。将通过使用AMSTAR2清单来评估每个系统审查的质量。道德和传播：这一伞审查预计将于2019年12月结束，结果将在同行评审期刊上发表，并通过会议介绍或海报传播。由于本系统审查和元分析中使用的所有数据已发布，因此该评论不需要道德批准。

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