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Association between atopic dermatitis and colorectal cancer risk: A nationwide cohort study

机译：特应性皮炎与结直肠癌风险之间的关联：全国范围的队列研究

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The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) has been a matter of scientific debate with mixed results. We conducted a nationwide cohort study to assess the association between AD and risk of CRC. Drawing on Taiwan's National Health Insurance Research Database , 46,703 patients with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients without AD (the non-AD cohort) were identified in the period between 2000 and 2008. Follow-up time was calculated from the date of entry in the cohort until the occurrence of a first CRC diagnosis, death, or the end of the observation period (December 31, 2013), whichever occurred first. Hazards ratios (HRs) and accompanying 95% confidence intervals (CIs) derived from the Fine-Gray competing risk model were used to estimate the association between AD and CRC risk. After multivariable adjustment, AD was associated with an increased risk of CRC (adjusted HR, 1.26; 95% CI, 1.14–1.40). Of note, a significant positive association between AD and CRC risk was evident in both men and women and in all age groups. In summary, this population-based cohort study revealed that AD was associated with an increased risk of CRC in an Asian population. It will be of interest for cohort studies with prediagnostic specimens to evaluate the potential relationship between AD and CRC using biomarkers for allergy status.
机译：特应性皮炎（AD）在结直肠癌（CRC）的发育中的作用是与混合结果进行科学辩论的问题。我们进行了一个全国队列研究，以评估广告与CRC的风险之间的关联。在台湾的国家健康保险研究数据库中绘制，46,703名患者（AD队列）和186,812名性别，年龄和指数年龄匹配的患者于2000年至2008年期间确定了未经广告（非广告队员）。从群组的进入日期之前计算出来的时间，直到第一次CRC诊断，死亡或观察期结束（2013年12月31日），以首先发生。危险比率（HRS）和伴随着95％的置信区间（CIS）衍生自微灰色竞争风险模型，用于估算广告和CRC风险之间的关联。经过多变量调节后，AD与CRC的风险增加有关（调整后的HR，1.26; 95％CI，1.14-1.40）。值得注意的是，在男女和所有年龄组中，广告和CRC风险之间的重大积极关联是明显的。总之，基于人群的队列研究表明，AD与亚洲人口中CRC的风险增加有关。对于群组研究，利用预测标本对群组进行了兴趣，可以使用生物标志物进行过敏状态评估AD和CRC之间的潜在关系。

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