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首页> 外文期刊>Medicine. >Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis
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Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis

机译：头部和颈部疣状癌：一种基于人口的发病率分析，治疗和预后

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Verrucous carcinoma is a rare variant of squamous cell carcinoma. The oral cavity, genitals, larynx, esophagus, and skin are usually affected, and the head and neck regions are the most affected areas. Few studies reported about head and neck verrucous carcinoma (VC) in the literature. Therefore, we conducted an extensive population-based study about the VCs to use population-based data to further investigate the incidence, treatment, and survival of head and neck verrucous carcinoma . Patients from Surveillance, Epidemiology, and End Results database ( SEER ) between 1973 and 2015 were brought into our study. The data of VCs and other head and neck malignancies (OHNMs) patients were extracted for analysis. We compared characteristics of patients with VC with those of patients with OHNMs. Results were obtained for 2039 cases of VC and 394,739 cases of OHNM. Compared to patients with OHNM, patients with VC were more often female (36.6% vs 31.1%; P .001), younger (median age 62 vs 67 years; P .001), and had a smaller tumor size ( P .001). VC cases were of lower histological grade and SEER stage ( P .001). The incidence of VC was 0.075 per 100,000 and decreased over time (annual change ?1.855%, P .001), whereas the incidence of OHNM showed no change. The primary treatment method for VC was surgery, with other treatments showing no significant therapeutic effect. VC is rare, with a decreasing incident trend. The outcome is better compared with OHNM patients. Surgery could significantly improve VC patients’ prognosis.
机译：疣状癌是一种稀有的鳞状细胞癌的罕见变体。口腔，生殖器，喉，食道和皮肤通常受到影响，头部和颈部区域是受影响最大的区域。少数研究报告了文献中的头部和颈部疣状癌（VC）。因此，我们对VC进行了广泛的基于人口的研究，以利用基于人群的数据进一步调查头部和颈部疣状癌的发病率，治疗和存活。 1973年至2015年间的监测，流行病学和最终结果数据库（SEER）的患者被带入了我们的研究。提取VCS和其他头部和颈部恶性肿瘤（OHNMS）患者的数据进行分析。我们将VC患者与OHNMS患者的特征进行了比较。得到2039例VC和394,739例OHNM的结果。与OHNM患者相比，VC患者较年轻（36.6％vs 31.1％; p <.001），年轻（中位数62岁vs 67岁; p <.001），并且具有较小的肿瘤大小（p < .001）。 VC病例是较低的组织学级和SEER阶段（P <.001）。 VC的发病率为每10万次为0.075，随时间减少（年变化？1.855％，P <.001），而OHNM的发生率没有变化。 vc的主要处理方法是手术，其它治疗没有显着治疗效果。 VC很少见，事件趋势降低。与OHNM患者相比，结果更好。手术可以显着提高VC患者的预后。

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