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Evaluating the association between avascular necrosis of femoral head and oral corticosteroids use in Taiwan

机译：评估台湾股骨头和口服皮质类固醇的血管坏死与台湾的关联

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The aim of this study was to assess a correlation between avascular necrosis of femoral head and oral corticosteroids use in the general population in Taiwan. A population-based case-control study was performed to analyze the database of Taiwan National Health Insurance Program . The study consisted of 3002 subjects aged 20 to 84 with newly diagnosed avascular necrosis of femoral head between 2000 and 2013 as the cases and 11279 sex-matched and age-matched subjects without avascular necrosis of femoral head as the matched controls. Use of oral corticosteroids was defined as subjects who had at least a prescription for oral corticosteroids before the index date. No use of oral corticosteroids was defined as subjects who did not have a prescription for oral corticosteroids before the index date. The logistic regression model revealed that subjects with avascular necrosis of femoral head were 1.65 times more likely to be exposed to oral corticosteroids than those subjects without avascular necrosis of femoral head (OR 1.65, 95% CI = 1.51–1.80). A sub-analysis revealed that there was a significant association between avascular necrosis of femoral head and increasing cumulative duration of oral corticosteroids for each additional month of use (OR 1.03, 95% CI = 1.02–1.03). A significant association is detected between avascular necrosis of femoral head and oral corticosteroids use in the general population in Taiwan. There is a duration-dependent effect of oral corticosteroids use on the risk of avascular necrosis of femoral head . Clinicians should be aware of the risk of avascular necrosis of femoral head when oral corticosteroids are prescribed for a long time.
机译：本研究的目的是评估股骨头和口腔皮质类固醇在台湾一般人群中使用的股骨头和口腔皮质类固醇之间的相关性。进行了一个基于人口的案例对照研究，分析了台湾国家健康保险计划的数据库。该研究由3002名受试者组成，2000至84岁，2000和2013年的新诊断为股骨头的血管坏死，作为病例和11279个性别匹配和年龄匹配的受试者，没有股骨头的股骨头的雌性坏死作为匹配的对照。口服皮质类固醇的使用被定义为在指数日期之前至少有口服皮质类固醇的处方。不使用口腔皮质类固醇被定义为在指数日期之前没有口服皮质类固醇的受试者。 Logistic回归模型显示，股骨头患有股骨头血管坏死的受试者比股骨头（或1.65,95％CI = 1.51-1.80）的缺血性坏死，对口腔皮头的血管头头的血管坏死的患者均为1.65倍。次分析表明，股骨头的血管坏死之间存在显着关联，并增加每次使用每一个月（或1.03,95％CI = 1.02-1.03）的口腔皮质类固醇的累积持续时间。在台湾一般人群中，股骨头和口腔皮质类固醇的缺血性坏死之间检测到一个重要的关联。口服皮质类固醇对股骨头缺血坏死风险的持续时间依赖性作用。临床医生应该意识到当长期规定口腔皮质类固醇时，股骨头患股骨头的风险。

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