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Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up

机译：STRETTA程序与质子泵抑制剂治疗不整理反流病：6个月的随访

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To compare the Stretta procedure with proton pump inhibitors for the treatment of nonerosive reflux disease (NERD). From July 2018 to April 2019, patients diagnosed with NERD and referred for treatment were enrolled. They were treated with either Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 months. The symptom control, quality of life, lower esophageal sphincter (LES) pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. The complications were assessed. The outcomes of the 2 groups were analyzed and compared. Twenty-eight patients in the Stretta group and 21 patients in the PPI group completed the 6-month follow-up. No severe adverse events occurred in both groups. Both interventions were effective in improvement of symptom and quality of life. The symptom score improvement was significantly superior in the Stretta group compared to the PPI group (6.3 ± 3.4 vs 8.5 ± 4.1, P = .03). LES pressure increased significantly in the Stretta group compared to the PPI group (14.2 ± 4.4 mm Hg vs 10.0 ± 4.0 mm Hg, P .01). Although both interventions improved 24-hour pH parameters, including number of acid episodes ( P = .27), acid exposure time ( P = .39), and DeMeester score ( P = .28), no difference was found between the 2 groups. Complete PPI cessation rate (82% vs 52%, P = .03) as well as satisfaction rate (89% vs 57%, P = .02) was much higher in Stretta group than those in the PPI group The Stretta procedure was safe and effective in the short term for the management of NERD. The Stretta procedure resulted in higher LES pressure and achieved better improvement of symptom control and PPI cessation than did PPI in the short term.
机译：比较用质子泵抑制剂的STRETTA程序，用于治疗非易性回流疾病（书呆子）。从2018年7月到2019年4月，患有书呆子并提到治疗的患者均已注册。它们用STRETTA程序或质子泵抑制剂（PPI）药物治疗并随访6个月。评估症状控制，生活质量，较低食管括约肌（LES）压力，24小时pH值参数，PPI使用和满意率。并发症被评估。分析了2组的结果并进行了比较。 28名患者在STRETTA组和21例PPI集团患者完成了6个月的随访。两组没有发生严重的不良事件。两种干预措施都有效地改善了症状和生活质量。与PPI组相比，STRETTA组的症状评分改善显着优异（6.3±3.4 Vs 8.5±4.1，p = .03）。与PPI组相比，STRETTA组在Stretta组中的压力显着增加（14.2±4.4mm Hg 10.0±4.0 mm Hg，P <.01）。虽然两种干预措施改善了24小时的pH参数，包括酸性发作数（p = .27），酸暴露时间（p = .39）和demeester评分（p = .28），在2组之间没有发现差异。完整的PPI停止速率（82％Vs 52％，P = .03）以及STRETTA组的满意度（89％Vs 57％，P = .02）比STRETTA程序安全的PPI集团中的那些更高在短期内有效，用于管理书呆子。 STRETTA程序导致较高的压力，并且在短期内比PPI更好地改善症状控制和PPI停止。

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