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Risk factors for gallstone disease in Shanghai: An observational study

机译：上海胆结石病的危险因素：观测学研究

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The purpose of this study was to evaluate related risk factors for gallstone disease in Shanghai. We analyzed successive physical examinations of 2288 adults who were recruited at the Jinshan Branch of the Sixth People's Hospital of Shanghai and Jinshan Hospital Affiliated to Fudan University Hospital from July 2010 to December 2012. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the influence factors on the risks of gallstone development. The incidence of gallstone disease was 4.11% (94/2,288). Older age (OR: 1.02; 95% CI: 1.00–1.03; P = .039), higher body weight (OR: 1.02; 95% CI: 1.00–1.04; P = .021), alanine transaminase activity (ALT) (OR: 1.02; 95% CI: 1.01–1.03; P = .001), total standard bicarbonate (SB) (OR: 1.04; 95% CI: 1.02–1.06; P .001), free SB (OR: 1.17; 95% CI: 1.12–1.21; P .001), and low density lipoprotein (LDL) levels (OR: 1.59; 95% CI: 1.32–1.91; P .001) were associated with an increased risk of gallstone disease. Based on univariate logistic analysis, increased triglyceride (TG) levels were associated with a reduced risk of gallstone disease (OR: 0.76; 95% CI: 0.60–0.97; P = .024). The results of multivariable logistic regression analysis showed higher LDL levels correlated with an increased risk of gallstone disease (OR: 1.92; 95% CI: 1.31–2.81; P .001), while age, weight, ALT, total SB, free SB, and TG levels did not affect the risk of gallstone disease. The although unadjusted results showed age, weight, ALT, total SB, free SB, TG, and LDL levels to be associated with the risk of gallstone disease, adjusting for potential factors revealed only increased LDL levels to be associated with an increased risk of gallstone disease.
机译：本研究的目的是评估上海胆结石病的相关危险因素。我们分析了2010年7月至2012年7月向复旦大学医院第六次人民医院的金山分行招募了2288名成年人的体检。差距（或者）置信区间的差距（或者）（CIS） ）用于测量胆结石发育风险的影响因素。胆结石疾病的发生率为4.11％（94 / 2,288）。年龄较大的年龄（或：1.02; 95％CI：1.00-1.03; p = .039），体重较高（或：1.02; 95％CI：1.00-1.04; p = .021），丙氨酸转氨酶活性（ALT）（ALT）（ALT）（ALT）（ALT）（ALT）（ALT）（ALT）（ALT）（ALT）（或者：1.02; 95％CI：1.01-1.03; p = .001），总标准碳酸氢盐（Sb）（或：1.04; 95％Ci：1.02-1.06; P <.001），免费SB（或：1.17; 95％CI：1.12-1.21; p <.001）和低密度脂蛋白（LDL）水平（或：1.59; 95％CI：1.32-1.91; p <.001）与胆结石疾病的风险增加有关。基于单变量物流分析，增加的甘油三酯（TG）水平与胆结石疾病的风险降低有关（或：0.76; 95％CI：0.60-0.97; P = .024）。多变量逻辑回归分析的结果显示出较高的LDL水平与胆结石疾病的风险增加相关（或：1.92; 95％CI：1.31-2.81; P <.001），而年龄，体重，ALT，总计Sb，免费SB而TG水平并未影响胆结石疾病的风险。虽然未经调整的结果表明年龄，体重，alt，总，Sb，免费的Sb，Tg和LDL水平与胆结石疾病的风险相关，调整潜在因素仅揭示了增加的LDL水平与胆结石的风险增加相关疾病。

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