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首页> 外文期刊>Medicine. >Effect of isolation practice on the transmission of middle east respiratory syndrome coronavirus among hemodialysis patients: A 2-year prospective cohort study
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Effect of isolation practice on the transmission of middle east respiratory syndrome coronavirus among hemodialysis patients: A 2-year prospective cohort study

机译：隔离实践对血液透析患者中​​东呼吸综合征冠状病毒的影响：2年的前瞻性队列研究

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Hemodialysis (HD) patients had a high rate of infection transmission and mortality during the middle east respiratory syndrome coronavirus (MERS-CoV) outbreak in Saudi Arabia. A standardized guideline on isolation technique for exposed HD patients is not available. Thus, this study aimed to evaluate the effect of different isolation strategies on the prevention of secondary viral transmission and clinical outcomes among exposed HD patients. During the 2015 MERS-CoV outbreak in Korea, 116 patients in 3 HD units were incidentally exposed to individuals with confirmed MERS-CoV infection and underwent different types of isolation , which were as follows: single-room isolation (n = 54, 47%), cohort isolation (n = 46, 40%), and self-imposed quarantine (n = 16, 13%). The primary outcome was rate of secondary viral transmission. The secondary outcome measures were changes in clinical and biochemical markers during the isolation period, difference in clinical and biochemical markers according to the types of isolation practice, and effect of isolation practice on patient survival. During a mean isolation period of 15 days, no further cases of secondary transmission were detected among HD patients. Plasma hemoglobin, serum calcium, and serum albumin levels and single-pool Kt/V decreased during the isolation period but normalized thereafter. Patients who were subjected to self-imposed quarantine had higher systolic and diastolic blood pressure, lower total cholesterol level, and lower Kt/V than those who underwent single-room or cohort isolation . During the 24-month follow-up period, 12 patients died. However, none of the deaths occurred during the isolation period, and no differences were observed in patient survival rate according to different isolation strategies. Although 116 participants in 3 HD units were incidentally exposed to MERS-CoV during the 2015 outbreak in Korea, strict patient surveillance and proper isolation practice prevented secondary transmission of the virus. Thus, a renal disaster protocol, which includes proper contact surveillance and isolation practice, must be established in the future to accommodate the needs of HD patients during disasters or outbreaks.
机译：血液透析（HD）患者在沙特阿拉伯中东呼吸道综合征冠状病毒（MERS-COV）爆发期间具有高感染传播和死亡率。不可用的暴露高清患者分离技术的标准化指南。因此，本研究旨在评估不同隔离策略对暴露高清患者中次生病毒传播和临床结果的影响。在2015年MERS-COV爆发韩国，36名高清单位的患者偶然暴露于具有证实的MERS-COV感染的个体，并进行了不同类型的分离，如下：单室隔离（n = 54,47％ ），队列分离（n = 46,40％）和自我施法的检疫（n = 16,13％）。主要结果是二次病毒传播速率。二次结果措施是在分离期间临床和生化标志物的变化，根据分离实践类型的临床和生化标志物的差异，以及孤立实践对患者存活的影响。在平均分离期间，在15天内，HD患者中未检测到次要传播的进一步情况。在隔离时段期间，血浆血红蛋白，血清钙和血清白蛋白水平和单池KT / V下降，但其后标准化。受到自我施加的患者的患者的收缩系和舒张血压，较低的总胆固醇水平，低于单室或队列分离的人低于KT / V。在24个月的后续期间，12名患者死亡。然而，根据不同的隔离策略，隔离期间没有发生死亡期间发生的死亡，并且在患者存活率中没有观察到差异。虽然在韩国的2015年爆发期间，3个高清单位的116名参与者偶然地接触到Mers-Cov，但严格的患者监测和适当的隔离实践阻止了病毒的二次传播。因此，必须在未来建立一个包括适当的接触监测和隔离实践的肾灾害协议，以适应灾害或爆发期间高清患者的需求。

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