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首页> 外文期刊>Medicine. >Evaluation of the age-related and gender-related differences in patients with primary insomnia by fractional amplitude of low-frequency fluctuation: A resting-state functional magnetic resonance imaging study
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Evaluation of the age-related and gender-related differences in patients with primary insomnia by fractional amplitude of low-frequency fluctuation: A resting-state functional magnetic resonance imaging study

机译：通过分数幅度的低频波动分数评估初级失眠患者的年龄相关和性别相关差异：静态功能磁共振成像研究

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Insomnia patients with different gender and age usually had different sleep experience. Primary insomnia (PI) has been considered to be a disorder of hyper-arousal in the physiologic, emotional, or cognitive network. Although the hyper-arousal brain regions can be shown by comparing the brain activity of PI patients with normal people at rest, whether the brain activity of PI patients varied according to age and gender and whether age and gender could affect the distribution of hyper-arousal brain regions are still worthy of further exploration. Hence, a resting state functional magnetic resonance imaging study (No. NCT02448602) was designed to observe the brain activity of thirty PI patients and 15 healthy controls (HCs). The brain activity in resting state was measured by calculating the fractional amplitude of low-frequency fluctuations (fALFF), which reflected the idiopathic activity level of neurons. Multiple regression was performed to investigate the age and gender-related differences of brain activity in PI patients ( P 50) with age and gender as covariates. The hyper-arousal brain regions were measured by comparing the fALFF of PI patients and HCs. Multiple regression ( P 50) was also performed for PI patients and HCs with group, age, and gender as covariates. The results suggested that the gender-related difference of brain activity mainly existed in superior temporal gyrus, cerebellum posterior lobe, middle frontal gyrus, and the age-related difference mainly existed in cerebellum anterior lobe, superior temporal gyrus, brainstem, parahippocampa gyrus, anterior cingulate, cingulate gyrus. In addition, the altered fALFF regions between PI and HCs mainly existed in superior temporal gyrus, posterior cingulate, anterior cingulate, cingulate gyrus, middle frontal gyrus. Furthermore, the gender factor could not influence the distribution of the altered regions. While the age factor could affect the distribution of the altered regions.
机译：性别和年龄不同的失眠患者通常具有不同的睡眠经验。原发性失眠（PI）被认为是生理，情感或认知网络中的超唤醒障碍。虽然通过比较休息态度的PI患者的脑活动，可以显示超唤起脑区域，但PI患者的大脑活动是否根据年龄和性别而变化，以及年龄和性别是否会影响超唤起的分布大脑地区仍然值得进一步探索。因此，静态功能磁共振成像研究（No.02448602）被设计为观察有三十PI患者和15例健康对照（HCS）的大脑活性。通过计算低频波动（FALFF）的分数幅度来测量静息状态的大脑活动，这反映了神经元的特发性活性水平。进行多元回归以研究PI患者脑活动的年龄和性别相关差异（P 50），随着年龄和性别作为协变量。通过比较PI患者和HCS的FALFF来测量超唤起脑区域。还对PI患者和HCS进行了多元回归（P 50），其中群体，年龄和性别作为协变量。结果表明，脑活动的性别相关差异主要存在于优越的颞叶，小脑后叶，中正面回到和年龄相关差异，主要存在于小脑前叶，优越的颞叶，脑干，Parahippocampa杂烩，前部铰接，铰接到回形。此外，PI和HCS之间的改变的FALFF区主要存在于优越的时间回归，后铰接，前铰链，铰接旋转，中正相。此外，性别因素不能影响改变区域的分布。虽然年龄因素可能影响改变区域的分布。

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