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首页> 外文期刊>Medicine. >Relationship between body mass index and arterial stiffness in a health assessment Chinese population
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Relationship between body mass index and arterial stiffness in a health assessment Chinese population

机译：体重指数与健康评估中的动脉僵硬的关系

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Pulse wave velocity (PWV) is a reliable measurement of arterial stiffness . Our study assesses the association between body mass index (BMI) and brachial-ankle PWV (baPWV) in a healthy cohort and seeks to explain possible mechanisms associated with the obesity paradox . A cross-sectional study was conducted in 578 normal individuals. The mean age was 48.3 ± 14.6 years, and 468 (81.0%) were men. 288 subjects (49.8%) were overweight and obese. baPWV and ankle-brachial index (ABI) were performed to evaluate arterial stiffness and atherosclerosis respectively. Normal weight was defined as 18.5 BMI 25 kg/m 2 , overweight as 25 ≤ BMI 28 kg/m 2 and obesity as BMI ≥28 kg/m 2 . The overweight/obese subjects had significantly higher baPWV than the normal-weight group (1490.0 ± 308.0/1445.2 ± 245.2 cm/s vs 1371.2 ± 306.4 cm/s, P .001). For the whole cohort, baPWV showed a significant positive correlation with BMI (r = 0.205, P .001). However, baPWV was significantly lower as BMI increased: 1490.0 ± 308.0 cm/s (overweight); 1445.2 ± 245.2 cm/s (obese); P .001) when adjusted for age, gender, heart rate, mean blood pressure, and cardiovascular risk factors (glucose, cholesterol, triglyceride, and low-density lipoprotein). For the whole cohort BMI was negatively associated with baPWV (β = ?0.06, P = .042). ABI showed no relationship with BMI. In a middle-age healthy Chinese population, arterial stiffness measured as baPWV increased with BMI. Evidence of reduced arterial stiffness with increasing BMI when accounting for all other cardiovascular risk factors may contribute to underlying factors involved in the obesity paradox that becomes more prominent with increasing age.
机译：脉搏波速度（PWV）是动脉刚度的可靠测量。我们的研究评估了健康的队列中体重指数（BMI）和肱骨脚踝PWV（BAPWV）之间的关联，并寻求解释与肥胖悖论相关的可能机制。在578个正常个体中进行横截面研究。平均年龄为48.3±14.6岁，468名（81.0％）是男性。 288名受试者（49.8％）超重和肥胖。进行BAPWV和脚踝 - 肱臂指数（ABI），分别进行了评估动脉僵硬和动脉粥样硬化。正常重量定义为18.5

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