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首页> 外文期刊>Medicine. >Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study
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Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study

机译：Letrozole和人脑血管促性腺激素用于克隆凤凰抗性多囊卵巢综合征患者的排卵诱导：随机对照研究

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Objective: To compare the effects of letrozole and human menopausal gonadotropin (HMG) in the treatment of patients with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC). Methods: A total of 96 clomiphene resistance polycystic ovary syndrome patients infertility were randomly divided into an LE group, and HMG group (n = 48). LE group orally received letrozole at 5.0 mg/d ?1 on the 3rd–5th days of menstrual cycle for 5 consecutive days, and 75 U/d ?1 HMG was given through intramuscular injection for 5 days starting from the third day of menstrual cycle in HMG group. Number of growing and mature follicles, serum E 2 (pg/mL), serum P (ng/mL), endometrial thickness, occurrence of pregnancy and miscarriage were observed. Results: There was no significant difference in the number of ovulation cycles between the 2 groups (53.6% vs 64.7%, P .05). The number of mature follicular cycles in the HMG group was higher than that of the letrozole group ( P .05) and abortion rate (6.2% vs 10.4%, P .05). There was no significant difference in the endometrial thickness between the 2 groups on the day of HCG injection [(9.1 ± 0.2) mm vs (10.7 ± 1.6) mm, P .05]; the serum estradiol (E2) was lower in the letrozole group. The incidence of ovarian cysts was lower than that of HMG group ( P .05). There was2 ovarian hyperstimulation syndrome in the letrozole group; the incidence of ovarian hyperstimulation syndrome in the HMG group was 12.5%. Conclusion: Letrozole- induced ovulation can obtain ovulation rate and pregnancy rate similar to gonadotropin , but reduce the risk associated with treatment. It can be used as an effective ovulation option for patients with polycystic ovary syndrome who are resistant to clomiphene.
机译：目的：比较Letrozole和人更年期促性腺激素（HMG）治疗含有克隆己柠檬酸酯（CC）的多囊卵巢综合征（PCOS）患者的影响。方法：总共96克隆抗性多囊卵巢综合征患者不孕症被随机分为LE组，HMG组（n = 48）。 Le Group在月经周期的第3-第5天的第3-5天的第3-5天左右口服Letrozole，通过肌肉注射，从月经周期第三天开始，通过肌肉注射给出75 u / d？1 hmg在HMG组中。观察到生长和成熟卵泡的数量，血清E 2（PG / mL），血清P（Ng / ml），子宫内膜厚度，妊娠和流产的发生。结果：2组之间的排卵循环数量没有显着差异（53.6％Vs 64.7％，p> .05）。 HMG组成熟滤泡循环的数量高于Letrozole基团（p，05）和流产率（6.2％vs 10.4％，p> .05）。 2组在HCG喷射日内的子宫内膜厚度差异没有显着差异[（9.1±0.2）mm Vs（10.7±1.6）mm，p> .05]; Letrozole基团中血清雌二醇（E2）较低。卵巢囊肿的发病率低于HMG组（P <.05）。 Letrozole组中有2种卵巢过度刺激综合征; HMG组中卵巢过度刺激综合征的发病率为12.5％。结论：食品诱导的排卵可以获得与促性腺激素类似的排卵率和妊娠率，但降低了与治疗相关的风险。它可以用作具有耐克隆己的多囊卵巢综合征患者的有效排卵选择。

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