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A systematic review and meta-analysis of the effects of early mobilization therapy in patients after cardiac surgery: A protocol for systematic review

机译：心脏手术后早期动员治疗患者效应的系统评价和荟萃分析：系统审查议定书

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Background: Prolonged hospitalization and immobility of critical care patients elevates the risk of long-term physical and cognitive impairments. However, the therapeutic effects of early mobilization have been difficult to interpret due to variations in study populations, interventions, and outcome measures. This systematic review and meta-analysis aims to assess the effects of early mobilization therapy for non-emergency cardiac surgery patients in the intensive care unit (ICU). Methods: The following databases will be used to search for relevant keywords: PubMed, Embase, CINAHL, PEDro, and the Cochrane Library from inception to September 2018 by 2 researchers independently. Randomized controlled trials (RCTs), will be included if patients are adults (≥18 years) admitted to any ICU for cardiac surgery due to cardiovascular disease and who are treated with experimental physiotherapy initiated in the ICU (pre, post, or perioperative). The Review Manager 5.3 will be used for meta-analysis and the evidence level will be assessed by using the method for Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Continuous outcomes will be presented as the weighted mean difference (WMD) or standardized mean difference (SMD) with 95% confidence interval (CI), while dichotomous data will be expressed as relative risk (RR) with 95% CI. If the included studies have existing heterogeneity (P 0.1), a random-effects model will be used. Otherwise, we will calculate using a fixed effects model. Results: This review will evaluate the effects of early mobilization on length of ICU and hospital stay, physical function and adverse events in patients with cardiac surgery patients in the ICU. Conclusion: This systematic review will comprehensively provide conclusive evidence of the therapeutic effect of early mobilization on cardiac surgery patients in the ICU. PROSPERO Research registration identifying number: CRD42019135338.
机译：背景：长期的住院治疗和临界护理患者的不动，提升了长期物理和认知障碍的风险。然而，由于研究群体，干预和结果措施的变化，早期动员的治疗效果难以解释。该系统审查和META分析旨在评估早期动员治疗对重症监护单元（ICU）的非急症心脏手术患者的影响。方法：下列数据库将用于搜索相关的关键词：PubMed，Embase，Cinahl，Pedro和Cochrane图书馆独立于2名研究人员从成立到2018年9月。将包括随机对照试验（RCT），如果患者是成人（≥18岁），因心血管疾病而入备任何ICU，并且在ICU中发起的实验性物理疗法治疗（预先，柱或围手术期）。审查经理5.3将用于元分析，并通过使用建议评估，开发和评估（等级）进行评级方法来评估证据水平。将呈递连续结果作为加权平均差（WMD）或标准化平均差异（SMD），具有95％置信区间（CI），而二分数据将表示为95％CI的相对风险（RR）。如果包括的研究具有现有的异质性（P <0.1），则将使用随机效应模型。否则，我们将使用固定效果模型计算。结果：本报告将评估早期动员在ICU中心脏手术患者患者的ICU和住院住院，物理功能和不良事件的影响。结论：该系统审查将全面提供关于ICU中心脏手术患者早期动员治疗效果的确凿证据。 Prospero Research注册识别号码：CRD42019135338。

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