...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Microbial Genomics >Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes
【24h】

Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes

机译：与其他临床表型相比，全基因组分析揭示了慢性阻塞性肺病的无缺失血液嗜血杆菌异常与慢性阻塞性肺疾病之间的基因含量差异

获取原文
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nontypeable Haemophilus influenzae (NTHi) colonizes human upper respiratory airways and plays a key role in the course and pathogenesis of acute exacerbations of chronic obstructive pulmonary disease (COPD). Currently, it is not possible to distinguish COPD isolates of NTHi from other clinical isolates of NTHi using conventional genotyping methods. Here, we analysed the core and accessory genome of 568 NTHi isolates, including 40 newly sequenced isolates, to look for genetic distinctions between NTHi isolates from COPD with respect to other illnesses, including otitis media, meningitis and pneumonia. Phylogenies based on polymorphic sites in the core-genome did not show discrimination between NTHi strains collected from different clinical phenotypes. However, pan-genome-wide association studies identified 79 unique NTHi accessory genes that were significantly associated with COPD. Furthermore, many of the COPD-related NTHi genes have known or predicted roles in virulence, transmembrane transport of metal ions and nutrients, cellular respiration and maintenance of redox homeostasis. This indicates that specific genes may be required by NTHi for its survival or virulence in the COPD lung. These results advance our understanding of the pathogenesis of NTHi infection in COPD lungs.
机译：不可缺乏血液植物流感（NTHI）殖民植入人的上呼吸道气道，并在慢性阻塞性肺病（COPD）急性加剧的过程和发病机制中发挥关键作用。目前，不可能使用常规基因分型方法将NTHI的COPD分离物与NTHI的其他临床分离株区分。在这里，我们分析了568个NTHI分离株的核心和辅助基因组，包括40个新测序的分离物，寻找来自COPD与其他疾病的NTHI分离物之间的遗传区别，包括中耳炎，脑膜炎和肺炎。基于核心基因组多态性位点的系统发育未显示从不同临床表型收集的NTHI菌株之间的辨别。然而，泛基因组 - 范围协会研究确定了与COPD显着相关的79个独特的NTHI辅助基因。此外，许多COPD相关的NTHI基因具有毒力，金属离子的跨膜和营养素的跨膜运输，细胞呼吸和维持的疣状相关的统一性，并且对氧化还原性稳态的维持。这表明NTHI可能需要特异性基因在COPD肺中的存活或毒力。这些结果促进了对Copd肺中Nthi感染的发病机制的理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号