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Control of Francisella tularensis Virulence at Gene Level: Network of Transcription Factors

机译:基因级别控制Francisella Tularisis毒力:转录因子网络

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Regulation of gene transcription is the initial step in the complex process that controls gene expression within bacteria. Transcriptional control involves the joint effort of RNA polymerases and numerous other regulatory factors. Whether global or local, positive or negative, regulators play an essential role in the bacterial cell. For instance, some regulators specifically modify the transcription of virulence genes, thereby being indispensable to pathogenic bacteria. Here, we provide a comprehensive overview of important transcription factors and DNA-binding proteins described for the virulent bacterium Francisella tularensis , the causative agent of tularemia. This is an unexplored research area, and the poorly described networks of transcription factors merit additional experimental studies to help elucidate the molecular mechanisms of pathogenesis in this bacterium, and how they contribute to disease.
机译:基因转录的调节是控制细菌内基因表达的复杂过程中的初始步骤。转录控制涉及RNA聚合酶的联合努力和许多其他调节因子。全球性还是局部,阳性或消极,监管机构在细菌细胞中起重要作用。例如,一些调节剂特异性地改变毒力基因的转录,从而对病原细菌不可或缺。在这里,我们提供了针对毒性细菌Francisella Tularentensis的重要转录因子和DNA结合蛋白质的全面概述,Tularia的致病剂。这是一个未探索的研究领域,并且描述的转录因子网络的额外额外的实验研究是帮助阐明这种细菌在这种细菌中发病机制的分子机制,以及它们如何促进疾病。

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