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首页> 外文期刊>Kazan Medical Journal >Evaluation of the state of tubular epithelium in low birth weight infants with ischemic nephropathy
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Evaluation of the state of tubular epithelium in low birth weight infants with ischemic nephropathy

机译：缺血性肾病患者低出生体重婴儿管状上皮状态的评价

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Aim. The study of the diagnostic value of KIM-1 and NGAL in urine and cystatin C in the blood plasma of low birth weight infants with ischemic nephropathy. Methods. 150 newborns were divided into 3 groups: main group 72 low birth weight infants with manifestations of ischemic nephropathy divided into three subgroups: group 1A mild (n=36), 1B moderate (n=20), 1C severe (n=16); comparioson group 28 low birth weight infants without the evidence of ischemic nephropathy; control group 50 healthy newborns (20 full-term and 30 preterm).To assess the state of tubular epithelium of the kidneys, the levels of KIM-1 and NGAL were measured in the urine of neonates, to assess the state of glomerular filtration the level of сystatin C in the blood plasma was determined. Samples of blood and urine were collected twice, on days 1 to 3 and 7 to 10. Biomarker levels were determined by solid-phase enzyme immunoassay. Results. In the main group on day 1 to 3 of life KIM-1 and NGAL in the urine were significantly elevated compared to the control group (p 0.001). On day 7 to 10 the level of KIM-1 in the urine in subgroup 1A decreased (0.980.09 ng/dl), while remaining significantly higher compared to the control group, and in subgroups 1B and 1C it increased to 1.240.10 and 1.360.12 ng/dl, respectively. On day 7 to 10 of life the concentration of NGAL in the urine of children of all three subgroups declined, remaining significantly high compared to the control values. Сoncentration of cystatin C was significantly high only in newborns of subgroup 1C (p 0.001). Conclusion. Molecules of NGAL and KIM-1 are early markers of the renal ischemic injury in low birth weight infants who suffered perinatal hypoxia, and cystatin C cannot be considered an early predictor of renal damage in low birth weight infants with ischemic nephropathy as its level in the blood rises only in severe damage.
机译：目标。缺血性肾病患者尿液中Kim-1和Ngal在尿液中尿液和胱抑素C的诊断价值研究。方法。将150名新生儿分为3组：主要组72低出生体重婴儿，缺血性肾病的表现分为三个亚组：第1A组温和（n = 36），1b中等（n = 20），1c严重（n = 16）;比较森组28低出生体重婴儿没有缺血性肾病的证据;对照组50健康新生儿（20个全冠和30个早产）。评估肾脏的管状上皮状态，在新生儿的尿液中测量Kim-1和Ngal的水平，以评估肾小球过滤状态测定血浆中Сystatinc的水平。收集血液和尿液的样品两次，在第1至3和3和7至10天。通过固相酶免疫测定法测定生物标志物水平。结果。在第1至3天的主要组中，与对照组相比，尿液中的尿液中的Kim-1和Ngal显着升高（p 0.001）。在第7至10天，亚组中尿液中的Kim-1水平降低（0.980.09 ng / dl），同时与对照组相比，剩余程度明显高，在亚组1b和1c中，它增加到1.240.10和1c。分别为1.360.12 ng / dl。在生命中的第7至10天，与控制值相比，所有三个亚组的儿童尿液中NGAL中NGAL的浓度明显高。在亚组1C的新生儿中，胱抑素C的综合性显着高（p 0.001）。结论。 NGAL和KIM-1的分子是患有围产期缺氧的低出生体重婴儿的肾缺血性损伤的早期标记，并且胱抑素C不能被认为是缺血性肾病的低出生体重婴儿肾损伤的早期预测因子作为其水平血液仅在严重的损伤中升起。

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