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首页> 外文期刊>Nature environment and pollution technology >Concentration of Trace Metals in Blood and the Relationship with Reproductive Hormones (Estradiol and Progesterone) of Obese Females Living Around A Mining Area in Brits, South Africa
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Concentration of Trace Metals in Blood and the Relationship with Reproductive Hormones (Estradiol and Progesterone) of Obese Females Living Around A Mining Area in Brits, South Africa

机译：血液中痕量金属的浓度和与生殖激素（雌二醇和孕酮）的关系，南非矿区居住在矿区矿区周围的矿区

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Obesity is a rapidly growing problem in South Africa, with 70% of women reported as being obese. Studies have reported that high levels of trace metals may impair the production of reproductive hormones, which may, in turn, interfere with normal oocyte development in females. This study investigated the concentrations of trace metals in blood samples of obese individuals living around a mining industry and examined the overall effect on reproductive hormones of these obese females. A mixed-method research approach consisting of qualitative and quantitative (cross-sectional descriptive survey) was used in the study. Only females with BMI ≥ 30 were allowed to participate in the study. Blood samples were collected in two 5 mL tubes from each of the participants. Concentrations of trace metals in the blood samples were determined by the use of ICP-MS. Hormonal level measurement was also carried out. The results showed that the trace metal concentrations in the blood samples of participants were in the order Mn > Cr > Co > As > Pb > Cd. The mean concentrations of Mn, Cr, Co and As were above the WHO standards. The hormonal analysis showed that there was a positive correlation between estradiol and progesterone levels with Mn concentration. Cr and As concentrations showed a negative correlation between estradiol and progesterone levels. Also, a negative correlation was established between estradiol levels with Pb and Cd concentrations. The study showed that exposure to trace metals as pollutants may have an impact on the general and reproductive health of obese females living around mining activities.
机译：肥胖是南非迅速增长的问题，70％的妇女报告为肥胖。研究报告称，高水平的痕量金属可能损害生殖激素的生产，又可以干扰女性的正常卵母细胞发育。本研究调查了在矿业周围的肥胖个人的血液样本中的痕量金属浓度，并检查了这些肥胖女性的生殖激素的总体影响。在研究中使用了一种由定性和定量（横截面描述性调查）组成的混合方法研究方法。只允许BMI≥30的女性参加该研究。从每个参与者中收集在两个5ml管中的血液样品。通过使用ICP-MS测定血液样品中痕量金属的浓度。还进行了激素水平测量。结果表明，参与者的血液样品中的痕量金属浓度在Un> Cr> Co> Cd中的顺序中。 Mn，Cr，Co的平均浓度高于WHO标准。荷尔蒙分析表明，雌二醇与孕酮水平与Mn浓度之间存在正相关性。 Cr和浓度显示雌二醇和孕酮水平之间的负相关性。而且，用Pb和Cd浓度在雌二醇水平之间建立了负相关。该研究表明，作为污染物的痕量金属暴露可能对生活在采矿活动周围的肥胖女性的一般和生殖健康产生影响。

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