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Exosome-mediated crosstalk between microglia and neural stem cells in the repair of brain injury

机译:微胶质细胞和神经干细胞之间的外出介导的串扰在脑损伤的修复中

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Brain injury, especially that caused by stroke, is a leading cause of morbidity and mortality worldwide. Numerous studies on the neuroprotective effects of neural stem cells (NSCs) after brain injury have shown that crosstalk among neural cells, including neuron–glial, glial–glial, NSC–neuronal and NSC–glial communication, plays a major role in post-injury repair. Therefore, a better understanding of the factors involved in the interactions between NSCs and other neural cells should advance the development of therapeutic strategies for brain injury. In this article, we discuss the role of exosomes in the crosstalk between NSCs and microglia, focusing on key exosomal proteins and microRNAs in brain injury progression and repair.
机译:脑损伤,特别是由中风引起的,是全世界发病率和死亡率的主要原因。大量研究脑损伤后神经干细胞(NSCs)的神经保护作用表明,神经细胞中的串扰,包括神经元胶质,神经神经胶质,NSC神经元和NSC-胶质通信,在后伤后发挥着重要作用修理。因此,更好地了解参与NSC和其他神经细胞之间的相互作用的因素,应该提高脑损伤治疗策略的发展。在本文中,我们讨论外来体在NSC和微胶质细胞之间的串扰中的作用,重点关注脑损伤的关键外出蛋白和微大疱疹进展和修复。

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