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Jidong cognitive impairment cohort study: objectives, design, and baseline screening

机译：冀东认知障碍队列研究：目标，设计和基线筛选

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The risk of dementia increases in patients with cognitive impairment. However, it is not clear what factors contribute to the onset of dementia in those with cognitive impairment. In this prospective cohort study, we will investigate the every-five-year incidence of cognitive impairment and prognostic factors for cognitive impairment. The Jidong cognitive impairment cohort was established from April 2012 to August 2015, during which we recruited 5854 healthy participants (55.1% male) older than 45 years (mean, 57 years). Participants received a health examination in the Staff Hospital, Jidong Oilfield Branch, China National Petroleum Corporation. Baseline data and blood samples were collected. Cognitive impairment was evaluated using the Mini-Mental State Examination, and was defined as a Mini-Mental State Examination score of less than 24. Dementia was assessed using the criteria of Diagnostic and Statistical Manual of Mental Disorders (Fourth edition), the International Working Group criteria, and the Mini-Mental State Examination score. The follow-up will continue until December 2024, during which a prognostic model will be constructed. The primary outcome is the presence/absence of dementia and the secondary outcome is quality of life. Baseline screening results showed the following: (1) Cognitive impairment was apparent in 320 participants (5.5%). These participants will be excluded from the Jidong cohort study, and the remaining participants will be followed up. (2) Of the 320 participants with cognitive impairment, there was a significantly higher prevalence of illiteracy than other education levels (35.9%, P 0.05). Age, arterial hypertension, alcohol consumption, and passive smoking differed significantly between the cognitive impairment and healthy groups (P 0.05). Multivariate logistic regression models showed that age (odds ratio [OR] = 1.059, 95% confidence interval [CI]: 1.044–1.074) and arterial hypertension (OR = 1.665, 95% CI: 1.143–2.427) were risk factors for mild cognitive impairment. With the increase of educational level (illiteracy, primary school, junior high school, high school, university, and above), cognitive impairment gradually decreased (OR 1, P 0.05). (3) This cohort study has initially screened for several risk factors for cognitive impairment at baseline, and subsequent prospective data will further describe, validate, and evaluate the effects of these risk factors on cognitive impairment and dementia. These results can provide clinical evidence for the early prevention of cognitive impairment and dementia. The study was approved by the Ethics Committee of Kailuan General Hospital of Tangshan City and the Medical Ethics Committee, Staff Hospital, Jidong Oilfield Branch, China National Petroleum Corporation on July 12, 2013 (approval No. 2013 YILUNZI 1).
机译：认知障碍患者痴呆症的风险增加。然而，目前尚不清楚因认知障碍的人中有助于痴呆症的发病。在这项未来的队列研究中，我们将调查认知障碍的每五年发病率和认知障碍的预后因素。冀东认知障碍队伍成立于2012年4月至2015年8月，在此期间，我们招募了5854名健康参与者（55.1％的男性）超过45年（平均，57岁）。与会者在中国石油公司冀东油田分公司员工医院收到了健康检查。收集基线数据和血液样本。使用迷你精神状态检查评估认知障碍，被定义为迷你精神状态检查评分少于24分。利用精神障碍诊断和统计手册（第四版），国际工作的标准评估痴呆症组标准和迷你精神状态考试分数。随访将继续到2024年12月，在此期间将构建预后模型。主要结果是痴呆的存在/不存在，二次结果是生活质量。基线筛选结果表明以下：（1）320名参与者（5.5％）中的认知障碍是显而易见的。这些参与者将被排除在冀东队列研究之外，其余的参与者将随访。 （2）320名参与者具有认知障碍，文盲患病率明显高于其他教育水平（35.9％，P <0.05）。年龄，动脉高血压，酒精消费和被动吸烟在认知障碍和健康组之间有显着不同（P <0.05）。多变量逻辑回归模型显示年龄（差距[或] = 1.059，95％置信区间[CI]：1.04-1.074）和动脉高血压（或= 1.665,95％CI：1.143-2.427）是轻度认知的危险因素损伤。随着教育程度的增加（文盲，小学，初中，高中，大学，及以上），认知障碍逐渐减少（或<1，P <0.05）。 （3）该队列研究最初筛选了基线认知障碍的几种风险因素，随后的前瞻性数据将进一步描述，验证和评估这些风险因素对认知障碍和痴呆症的影响。这些结果可以提供早期预防认知障碍和痴呆的临床证据。该研究得到了唐山市凯源综合医院伦理委员会和医疗伦理委员会，工作人员医院，冀东油田分公司，中国全国石油公司，于2013年7月12日批准（批准2013年yilunzi 1）。

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